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Echinocandins

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Definition: Cyclic hexapeptides of proline-ornithine-threonine-proline-threonine-serine. The cyclization with a single non-peptide bond can lead them to be incorrectly called DEPSIPEPTIDES, but the echinocandins lack ester links. Antifungal activity is via inhibition of 1,3-beta-glucan synthase production of BETA-GLUCANS.     
Pharmacological Action Antifungal Agents 		Other names Pneumocandins; Mulundocandins; Aculeacins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
micafungin  0   *Echinocandins *Lipopeptides.
Pharma Action Antifungal Agents 		J Antibiot (Tokyo) 1999 Jul;52(7):674-6MYCAMINE
echinocandin-binding protein, 40-kDa, Candida albicans  0   *Fungal Proteins Echinocandins. Antimicrob Agents Chemother 1998 May;42(5):1187-94
caspofungin  0   *Echinocandins.
Pharma Action Antifungal Agents 		Antimicrob Agents Chemother 1997 Feb;41(2):331-6CASPOFUNGIN ACETATE; CANCIDAS
anidulafungin  0   *Echinocandins.
Pharma Action Antifungal Agents 		Antimicrob Agents Chemother 1996 Aug;40(8):1811-6ERAXIS
LY 307853  0   *Echinocandins. Antimicrob Agents Chemother 1996 Aug;40(8):1811-6
FKS1 protein, S cerevisiae  EC 2.4.1.34   *Glucosyltransferases *Membrane Proteins *Saccharomyces cerevisiae Proteins *Echinocandins. Gene 1994 Dec 30;151(1-2):61-71
pneumocandin D(0)  144087-99-0   *Echinocandins. J Antibiot (Tokyo) 1994 Jul;47(7):755-64
pneumocandin B(0)  135575-42-7   *Echinocandins. J Antibiot (Tokyo) 1992 Dec;45(12):1853-66
pneumocandin C(0)  144074-96-4   *Echinocandins. J Antibiot (Tokyo) 1992 Dec;45(12):1853-66
deoxymulundocandin  138626-63-8 L-Proline, (4R,5R)-4,5-dihydroxy-N2-(12-methyl-1-oxotetradecyl)-L-ornithyl-L-threonyl-trans-4-hydroxy-L-prolyl-4-(4-hydroxyphenyl)-L-threonyl-L-seryl-3-hydroxy-4-methyl-, cyclic (6-1)-peptide, (2alpha,3beta,4beta)  *Echinocandins Aspergillus. J Antibiot (Tokyo) 1992 May;45(5):618-23
pneumocandin A(0)  120300-08-5   *Echinocandins. J Antibiot (Tokyo) 1989;42(2):168
mulundocandin  108351-20-8 Echinocandin B, 1-(4,5-dihydroxy-N-(12-methyl-1-oxotetradecyl)ornithine)-5-serine  *Echinocandins. J Antibiot (Tokyo) 1987;40(3):275
cilofungin  79404-91-4 Echinocandin B, 1-((4R,5R)-4,5-dihydroxy-N2-(4-(octyloxy)benzoyl)-L-ornithine)  *Echinocandins.
Pharma Action Antifungal Agents 		Mycopathologia 1984;86(1):45
papulacandins  61036-45-1 Papulacandin  *Aminoglycosides *Echinocandins. Helv Chim Acta 60(2):578;1977; J Antibiot (Tokyo) 30(4):289;1977
echinocandin B  54651-05-7   *Fungal Proteins *Echinocandins beta-Glucans.
Pharma Action Antifungal Agents 		Helv Chim Acta 57(8):2459;1974

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