Definition: A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an N-terminal catalytic domain and a C-terminal PROLINE-rich domain. The phosphatase subtype is predominantly expressed in LYMPHOCYTES and plays a key role in the inhibition of downstream T-LYMPHOCYTE activation. Polymorphisms in the gene that encodes this phosphatase subtype are associated with a variety of AUTOIMMUNE DISEASES.
Other names Tyrosine Protein Phosphatase, Non Receptor Type 22; Protein Tyrosine Phosphatase, Non Receptor Type 22; Protein Tyrosine Phosphatase Lyp; PTPase, Lyp1; Tyrosine Protein Phosphatase, Non-Receptor Type 22; PTPase, Lyp2; Protein-Tyrosine Phosphatase Lyp; PTPase Lyp; Lyp2 PTPase; Lyp1 PTPase; Lymphoid Phosphatase
