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Group IV Phospholipases A2

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Definition: A cytosolic phospholipase A2 group that plays an important role in the release of free ARACHIDONIC ACID, which in turn is metabolized to PROSTAGLANDINS by the CYCLOOXYGENASE pathway and to LEUKOTRIENES by the 5-LIPOXYGENASE pathway.      Other names PLA2-IV; cPLA2 gamma; cPLA2 alpha; Phospholipase A2 gamma; Phospholipase A2 beta; Phospholipase A2 alpha; cPLA2-gamma; cPLA2-alpha; Phospholipase A2-gamma; Phospholipase A2-beta; Phospholipase A2-alpha; Phospholipase A2, Group IVF; Phospholipase A2, Group IVE; Phospholipase A2, Group IVD; Phospholipase A2, Group IVC; Phospholipase A2, Group IVB; Phospholipase A2 IV; Phospholipase A2 Group IVA; Phospholipase A(2)alpha; PLA(2)-IV
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-(5-carboxypentanoyl)-1-(3-(4-octylphenoxy)-2-oxopropyl)indole-5-carboxylic acid  0   *Indoles Group IV Phospholipases A2/antagonists & inhibitors. Br J Dermatol. 2012 Feb;166(2):306-16
3-isobutanoyl-1-(2-oxo-3-(4-phenoxyphenoxy)propyl)indole-5-carboxylic acid  0   *Indoles *Phenyl Ethers Group IV Phospholipases A2/antagonists & inhibitors. J Med Chem 2010 Jul 22;53(14):5165-78
N-((4-(biphenyl-2-ylmethoxy)-1-(2-(4-fluorobenzoyl)benzoyl)pyrrolidin-2-yl)methyl)-4-((2,4-dioxothiazolidin-5-ylidene)methyl)benzamide  0   *Pyrrolidines *Thiazolidinediones Group IV Phospholipases A2/antagonists & inhibitors. Inflamm Res 2010 Jan;59(1):53-62
4-(3-(5-chloro-2-(2-(((2,6-dimethylbenzyl)sulfonyl)amino)ethyl)-1-(diphenylmethyl)-1H-indol-3-yl)propyl)benzoic acid  0   *Sulfonamides *Benzoic Acids Group IV Phospholipases A2/antagonists & inhibitors. J Med Chem 2008 Jun 26;51(12):3388-413
efipladib  0   *Sulfonamides *Benzoic Acids Group IV Phospholipases A2/antagonists & inhibitors. J Med Chem 2008 Jun 26;51(12):3388-413
N-(-4-(N-(biphenyl-2-ylmethyl)-N-2-methylpropylamino)- 1-(2-(2,4-difluorobenzoyl)benzoyl)pyrrolidin- 2-yl)methyl-3-(4-(2,4-dioxothiazolidin-5-ylidenemethyl) phenyl)acrylamide  0   *Acrylamides *Thiazolidinediones Group IV Phospholipases A2/antagonists & inhibitors. Pharmacology 2008;81(4):301-11
Pla2g4f protein, mouse  EC 3.1.1.4   *Group IV Phospholipases A2. J Biol Chem 2007 Apr 20;282(16):11676-86
PLA2G4F protein, human  EC 3.1.1.4   *Group IV Phospholipases A2.
PLA2G4E protein, human  EC 3.1.1.4   *Group IV Phospholipases A2.
PLA2G4D protein, human  EC 3.1.1.4   *Group IV Phospholipases A2.
Pla2g4c protein, mouse  EC 3.1.1.4   *Group IV Phospholipases A2.
Pla2g4b protein, mouse  EC 3.1.1.4   *Group IV Phospholipases A2.
PLA2G4B protein, human  EC 3.1.1.4   *Group IV Phospholipases A2.
Pla2g4a protein, rat  EC 3.1.1.4   *Group IV Phospholipases A2.
Pla2g4a protein, mouse  0   *Group IV Phospholipases A2.
PLA2G4A protein, human  EC 3.1.1.4   *Group IV Phospholipases A2.
PLA2G4C protein, human  EC 3.1.1.-   *Group IV Phospholipases A2. J Interferon Cytokine Res 2002 Sep;22(9):947-55

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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