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Peroxiredoxins

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Definition: A family of ubiquitously-expressed peroxidases that play a role in the reduction of a broad spectrum of PEROXIDES like HYDROGEN PEROXIDE; LIPID PEROXIDES and peroxinitrite. They are found in a wide range of organisms, such as BACTERIA; PLANTS; and MAMMALS. The enzyme requires the presence of a thiol-containing intermediate such as THIOREDOXIN as a reducing cofactor.     
Examples Peroxiredoxin III; Peroxiredoxin VI 		Other names Thioredoxin Dependent Peroxide Reductase 2; Thioredoxin Dependent Peroxide Reductase 1; Thiol Specific Antioxidant Protein; Hydroperoxide Reductase, Alkyl; Thioredoxin-Dependent Peroxide Reductase 2; Thioredoxin-Dependent Peroxide Reductase 1; Thioredoxin Peroxidase PMP20; Thioredoxin Peroxidase 2; Thioredoxin Peroxidase 1; Thioredoxin Peroxidase; Thiol-Specific Antioxidant Protein; Protector Protein (Mixed-Function Oxidase Systems); Peroxiredoxin-4; Peroxiredoxin V; Peroxiredoxin IV; Peroxiredoxin II; Peroxiredoxin I; Peroxiredoxin 5; Peroxiredoxin 4; Peroxiredoxin 2
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
peroxiredoxin 6005, Drosophila  0   *Drosophila Proteins *Peroxiredoxins. Mech Dev 2011 Mar-Apr;128(3-4):191-9
PAMM protein, human  0   *Peroxiredoxins Osteoclasts. Antioxid Redox Signal. 2010 Jul 1;13(1):27-37
PAMM protein, mouse  0   *Peroxiredoxins Osteoclasts. Antioxid Redox Signal. 2010 Jul 1;13(1):27-37
PXN-2 protein, C elegans  EC 1.11.1.15   *Caenorhabditis elegans Proteins *Peroxiredoxins. Development. 2010 Nov;137(21):3603-13
bacterioferritin comigratory protein, S pombe  EC 1.11.1.15   *Schizosaccharomyces pombe Proteins *Peroxiredoxins. J Microbiol 2009 Feb;47(1):60-7
PRDX-2 protein, C elegans  EC 1.11.1.15   *Caenorhabditis elegans Proteins *Peroxiredoxins. Proc Natl Acad Sci U S A 2008 Dec 16;105(50):19839-44
Tpx1 protein, S pombe  0   *Schizosaccharomyces pombe Proteins *Peroxiredoxins.
Prdx4 protein, rat  EC 1.11.1.15   *Peroxiredoxins.
Prdx4 protein, mouse  EC 1.11.1.15   *Peroxiredoxins.
PRDX4 protein, human  EC 1.11.1.15   *Peroxiredoxins.
Prdx5 protein, mouse  EC 1.11.1.15   *Peroxiredoxins.
PRDX5 protein, human  EC 1.11.1.15   *Peroxiredoxins.
PRDX1 protein, human  EC 1.11.1.15   *Peroxiredoxins.
ahpF protein, E coli  EC 1.6.4.-   *Escherichia coli Proteins *Peroxiredoxins.
ahpC protein, E coli  EC 1.11.1.15   *Escherichia coli Proteins *Peroxiredoxins.
AHP1 protein, S cerevisiae  0   *Peroxiredoxins.
peroxiredoxin Q, Arabidopsis  EC 1.11.1.15   *Arabidopsis Proteins *Peroxiredoxins. Plant J 2006 Mar;45(6):968-81
2-cys peroxiredoxin, human  EC 1.11.1.15   *Peroxiredoxins. Anal Biochem. 2005 Mar 15;338(2):216-23
2-Cys peroxiredoxin A, Arabidopsis  EC 1.11.1.15   *Arabidopsis Proteins *Peroxiredoxins. Plant Cell Physiol 2004 Aug;45(8):997-1006
Prdx1 protein, mouse  EC 1.11.1.15   *Peroxiredoxins.
Prdx1 protein, rat  EC 1.11.1.14   *Peroxiredoxins.
2-Cys peroxiredoxin, Plasmodium falciparum  EC 1.11.1.15   *Peroxiredoxins. FEBS Lett 2003 Jul 17;547(1-3):140-4
BAS1 protein, Arabidopsis  EC 1.11.1.15   *Arabidopsis Proteins *Peroxiredoxins. Plant J 1997 Jul;12(1):179-90
peroxiredoxin, Fasciola hepatica  EC 1.11.1.14   *Peroxiredoxins. Parasitology 1997 Jul;115( Pt 1):101-4
TRX1 protein, S cerevisiae  0   *Membrane Proteins *Saccharomyces cerevisiae Proteins *Peroxiredoxins. Genetics 1994 Mar;136(3):1075-86; Plant Mol Biol 1996 Nov;32(4):653-62
PER1 protein, Hordeum vulgare  0   *Plant Proteins *Peroxiredoxins. Plant Mol Biol 1996 Sep;31(6):1205-16
PRDX2 protein, human  EC 1.11.1.15   *Peroxiredoxins Cytotoxicity, Immunologic Oxidation-Reduction. Biochem Biophys Res Commun 1994 Feb 28;199(1):83-8

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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