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Ghrelin

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Definition: A 28-amino acid, acylated, orexigenic peptide that is a ligand for GROWTH HORMONE SECRETAGOGUE RECEPTORS. Ghrelin is widely expressed but primarily in the stomach in the adults. Ghrelin acts centrally to stimulate growth hormone secretion and food intake, and peripherally to regulate energy homeostasis. Its large precursor protein, known as appetite-regulating hormone or motilin-related peptide, contains ghrelin and obestatin.      Other names Precursor, Motilin-Related Peptide; Precursor, Ghrelin; Peptide Precursor, Motilin-Related; Motilin Related Peptide Precursor; Motilin Related Peptide; Ghrelin Obestatin Preprohormone; Appetite Regulating Hormone; Ppghrelin; PpMTLRP; Obestatin; Motilin-Related Peptide Precursor; Motilin-Related Peptide; Ghrelin-Obestatin Preprohormone; Ghrelin Precursor; Gastric MLTRP; GHRL Protein; Appetite-Regulating Hormone
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
BIM-28125  0   Ghrelin/*analogs & derivatives. Pituitary. 2007;10(3):267-74
RC-1291  0   Ghrelin/*analogs & derivatives. Oncologist 2007 May;12(5):594-600
GHRL protein, human  0   *Ghrelin.
(Trp3, Arg5)-ghrelin(1-5)  0   *Ghrelin. Peptides. 2006 Jul;27(7):1632-7
obestatin, human  0   *Ghrelin. Science 2005 Nov 11;310(5750):996-9
ghrelin, des-n-octanoyl  0   *Ghrelin. Biochem Biophys Res Commun 2000 Dec 29;279(3):909-13
ghrelin, des-Gln(14)  0   *Ghrelin. J Biol Chem 2000 Jul 21;275(29):21995-2000

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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