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Oncostatin M

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Definition: A cytokine with both pro- and anti-inflammatory actions that depend upon the cellular microenvironment. Oncostatin M is a 28 kDa monomeric glycoprotein that is similar in structure to LEUKEMIA INHIBITORY FACTOR. Its name derives from the the observation that it inhibited the growth of tumor cells and augmented the growth of normal fibroblasts.     
Pharmacological Action Antineoplastic Agents; Growth Inhibitors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Osm protein, mouse  0   *Oncostatin M.
OSM protein, human  0   *Oncostatin M.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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