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Interleukin-1 Receptor Accessory Protein

More information in Books or onNLM PubMed
Definition: A protein that takes part in the formation of active interleukin-1 receptor complex. It binds specifically to INTERLEUKIN-1 and the INTERLEUKIN-1 RECEPTOR TYPE I at the cell surface to form a heterotrimeric complex that brings its cytoplasmic domain into contact with the cytoplasm domain of the TYPE-I INTERLEUKIN-1 RECEPTOR. Activation of intracellular signal transduction pathways from the receptor is believed to be driven by this form of cytoplasmic interaction.  Do not confuse with INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN    Other names Interleukin 1 Receptor Accessory Protein; IL-1RAcP
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
interleukin-1 receptor accessory protein-like 1, mouse  0   *Interleukin-1 Receptor Accessory Protein. Eur J Neurosci. 2009 Oct;30(8):1476-86.
rilonacept  0   *Recombinant Fusion Proteins Receptors, Interleukin-1 Type I Interleukin-1 Receptor Accessory Protein. Arthritis Rheum 2008 Aug;58(8):2432-42ARCALYST
IL1RAPL1 protein, rat  0   *Interleukin-1 Receptor Accessory Protein. Proc Natl Acad Sci U S A 2007 May 22;104(21):9063-8
Il1rap protein, mouse  0   *Interleukin-1 Receptor Accessory Protein.
Il1rap protein, rat  0   *Interleukin-1 Receptor Accessory Protein.
IL1RAP protein, human  0   *Interleukin-1 Receptor Accessory Protein.
IL1RAPL2 protein, human  0   *Interleukin-1 Receptor Accessory Protein. Eur J Hum Genet 2000 Feb;8(2):87-94
IL1RAPL1 protein, human  0   *Interleukin-1 Receptor Accessory Protein. Eur J Hum Genet 2000 Feb;8(2):87-94

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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