Cytochrome P-450 CYP27A1 (definition)

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Cytochrome P-450 CYP27A1

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Definition: An NAPH-dependent cytochrome P450 enzyme that catalyzes the oxidation of the side chain of sterol intermediates such as the 27-hydroxylation of 5-beta-cholestane-3-alpha,7-alpha, 12-alpha-triol. Cytochrome P-450 CYP27A1 is a mitochondrial enzyme; however microsomal-derived homologs of the enzyme have been identified and are included under this heading.

Other names Vitamin D3 25 Hydroxylase; Sterol 27 Hydroxylase; Sterol 26 Hydroxylase; Steroid 27 Hydroxylase; Steroid 25 Hydroxylase; P450c26-25, Cytochrome; P450 CYP27, Cytochrome; P-450 CYP2R1, Cytochrome; P-450 CYP27A1, Cytochrome; Cytochrome P450c26 25; Cytochrome P 450 Sterol 26 Hydroxylase; Cytochrome P 450 Steroid 27 Hydroxylase; Cytochrome P 450 CYP2R1; Cytochrome P 450 CYP27A1; Cholestanetriol 26 Monooxygenase; CYP2R1, Cytochrome P-450; CYP27A1, Cytochrome P-450; CYP27, Cytochrome P450; C27 Steroid 26 Hydroxylase; Vitamin D3 25-Hydroxylase

Substance	CAS Registry & name	Categories
Cyp2r1 protein, mouse	EC 1.14.13.15	*Cytochrome P-450 CYP27A1.
CYP2R1 protein, human	EC 1.14.13.15	*Cytochrome P-450 CYP27A1.
Cyp27a1 protein, mouse	EC 1.14.13.15	*Cytochrome P-450 CYP27A1.
CYP27A1 protein, human	EC 1.14.13.15	*Cytochrome P-450 CYP27A1.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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