beta 2-Glycoprotein I (definition)

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ψ ψ	beta 2-Glycoprotein I

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Definition: A 44-kDa highly glycosylated plasma protein that binds phospholipids including CARDIOLIPIN; APOLIPOPROTEIN E RECEPTOR; membrane phospholipids, and other anionic phospholipid-containing moieties. It plays a role in coagulation and apoptotic processes. Formerly known as apolipoprotein H, it is an autoantigen in patients with ANTIPHOSPHOLIPID ANTIBODIES.

Pharmacological Action Anticoagulants

Other names beta2 Glycoprotein I; beta 2 Glycoprotein I; Endothelial Cell Viability Maintaining Factor; EC VMFa; Cofactor, Anticardiolipin; beta2-Glycoprotein I; beta(2)GPI; Endothelial Cell-Viability Maintaining Factor; EC-VMFa; Apo H; Anticardiolipin Cofactor; Apolipoprotein H

Substance	CAS Registry & name	Categories	Source	Drugs*
asialo-beta 2-glycoprotein I	0	*beta 2-Glycoprotein I Apolipoproteins.	J Biochem (Tokyo) 1995 Jul;118(1):129-36

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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