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Receptors, TNF-Related Apoptosis-Inducing Ligand

More information in Books or onNLM PubMed
Definition: Tumor necrosis factor receptor family members that are widely expressed and play a role in regulation of peripheral immune responses and APOPTOSIS. The receptors are specific for TNF-RELATED APOPTOSIS-INDUCING LIGAND and signal via conserved death domains that associate with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.      Other names TRAIL-4 Receptor; TRAIL-2 Receptor; TNF Related Apoptosis Inducing Ligand Receptors; TNF Related Apoptosis Inducing Ligand Receptor 2; Receptors, TNF Related Apoptosis Inducing Ligand; TRAIL-1 Receptor; Receptor-4, Death; Receptor, TRAIL 4; Receptor, TRAIL 2; Receptor, TRAIL 1; Receptor, DR5; Receptor, DR4; Receptor, DCR2; Receptor, APO2; Receptor 4, TRAIL; Death Receptor 5; Death Receptor 4; Tumor Necrosis Factor Receptor Superfamily, Member; Tumor Necrosis Factor Receptor Superfamily, Member; TRAIL Receptors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
soluble tumor necrosis factor-related apoptosis-inducing ligand (114-281), rat  0   *Peptide Fragments *Receptors, TNF-Related Apoptosis-Inducing Ligand. Cancer Biol Ther 2009 Aug;8(15):1517-24
lexatumumab  0   *Antibodies, Monoclonal Receptors, TNF-Related Apoptosis-Inducing Ligand.
Tnfrsf10b protein, rat  0   *Receptors, TNF-Related Apoptosis-Inducing Ligand.
Tnfrsf10b protein, mouse  0   *Receptors, TNF-Related Apoptosis-Inducing Ligand.
TNFRSF10B protein, human  0   *Receptors, TNF-Related Apoptosis-Inducing Ligand.
TNFRSF10A protein, human  0   *Receptors, TNF-Related Apoptosis-Inducing Ligand. Science 1997 Apr 4;276(5309):111-3

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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