Definition: A cytoplasmic serine threonine kinase involved in regulating CELL DIFFERENTIATION and CELLULAR PROLIFERATION. Overexpression of this enzyme has been shown to promote PHOSPHORYLATION of BCL-2 PROTO-ONCOGENE PROTEINS and chemoresistance in human acute leukemia cells.
Other names Serine-Threonine Kinase, PKC-alpha; PKC alpha Serine Threonine Kinase; Protein Kinase C(alpha); Protein Kinase C alpha; PKC-alpha Serine-Threonine Kinase