encyclopedia of medical concepts
ψ 

Core Binding Factor Alpha 2 Subunit

More information in Books or onNLM PubMed
Definition: A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain. Runx1 is frequently mutated in human LEUKEMIAS.  see SCR for organism-specific terms    Other names Runt Related Transcription Factor 1; Core Binding Factor Alpha 2 Protein; Runx1 Protein; Runt-Related Transcription Factor 1; Pebp2a2 Protein; Core-Binding Factor Alpha 2 Protein; Acute Myeloid Leukemia 1D Protein; Acute Myeloid Leukemia 1C Protein; Acute Myeloid Leukemia 1B Protein; Acute Myeloid Leukemia 1A Protein; Acute Myeloid Leukemia 1 Protein; AML1D Protein; AML1C Protein; AML1B Protein; AML1A Protein
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
AML1-FOG2 fusion protein, human  0   *Oncogene Proteins, Fusion *Core Binding Factor Alpha 2 Subunit. Blood 2005 Jun 1;105(11):4523-6
RUNX1 protein, human  0   *Core Binding Factor Alpha 2 Subunit.
Runx1 protein, rat  0   *Core Binding Factor Alpha 2 Subunit.
Runx1 protein, mouse  0   *Core Binding Factor Alpha 2 Subunit.
TEL-RUNX1 fusion protein, human  0   *Oncogene Proteins, Fusion *Core Binding Factor Alpha 2 Subunit. Mol Cells 2004 Apr 30;17(2):217-22
runx1 protein, zebrafish  0   *Zebrafish Proteins *Core Binding Factor Alpha 2 Subunit. Exp Hematol 2002 Dec;30(12):1381-9
AML1-MDS1-EVI1 fusion protein, human  0   *Repressor Proteins *Oncogene Proteins, Fusion *Core Binding Factor Alpha 2 Subunit. Oncogene 2002 May 9;21(20):3232-40
AML1-AMP19 fusion protein, human  0   *Oncogene Proteins, Fusion *Core Binding Factor Alpha 2 Subunit. Blood 2001 Apr 1;97(7):2168-70
CBFA2-EAP fusion protein, human  0   *Oncogene Proteins, Fusion *Core Binding Factor Alpha 2 Subunit. Leuk Res 2000 Jan;24(1):11-7
CBFA2-MDS1 protein, human  0   *Oncogene Proteins, Fusion *Core Binding Factor Alpha 2 Subunit. Leuk Res 2000 Jan;24(1):11-7
AML1-MTG16 protein, human  0   *Oncogene Proteins, Fusion *Core Binding Factor Alpha 2 Subunit Neoplasm Proteins. Blood 1998 Jun 1;91(11):4028-37
AML1-ETO fusion protein, human  0   *Oncogene Proteins, Fusion *Core Binding Factor Alpha 2 Subunit. Haematologica 1997 May-Jun;82(3):364-70
TEL-AML1 fusion protein  0   *Oncogene Proteins, Fusion *Core Binding Factor Alpha 2 Subunit Precursor Cell Lymphoblastic Leukemia-Lymphoma. Blood 1996 Dec 1;88(11):4252-8

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy