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Succinate-Semialdehyde Dehydrogenase

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Definition: An enzyme that plays a role in the GLUTAMATE and butanoate metabolism pathways by catalyzing the oxidation of succinate semialdehyde to SUCCINATE using NAD+ as a coenzyme. Deficiency of this enzyme, causes 4-hydroxybutyricaciduria, a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA).      Other names Semialdehyde Dehydrogenase, Succinic; Semialdehyde Dehydrogenase, Succinate; Dehydrogenase, Succinic Semialdehyde; Dehydrogenase, Succinate-Semialdehyde; Dehydrogenase, Succinate Semialdehyde; Succinic Semialdehyde Dehydrogenase; Succinate Semialdehyde Dehydrogenase; NAD(+)-Dependent Succinic Semialdehyde Dehydrogena
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
gabD protein, E coli  EC 1.2.1.24   *Escherichia coli Proteins *Succinate-Semialdehyde Dehydrogenase. Biochem Biophys Res Commun. 2010 Jan 29;392(1):106-11
succinic semialdehyde dehydrogenase deficiency  0   *Amino Acid Metabolism, Inborn Errors Succinate-Semialdehyde Dehydrogenase/deficiency.
Aldh5a1 protein, mouse  EC 1.2.1.24   *Succinate-Semialdehyde Dehydrogenase. Neurochem Int 2007 Mar;50(4):653-9
Aldh5a1 protein, rat  EC 1.2.1.24   *Succinate-Semialdehyde Dehydrogenase.
ALDH5A1 protein, human  EC 1.2.1.24   *Succinate-Semialdehyde Dehydrogenase.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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