encyclopedia of medical concepts
ψ
ψ
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Receptors, Serotonin, 5-HT4
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Definition
: A subtype of G-protein-coupled SEROTONIN receptors that preferentially couple to GS STIMULATORY G-PROTEINS resulting in increased intracellular CYCLIC AMP. Several isoforms of the receptor exist due to ALTERNATIVE SPLICING of its mRNA.
Other names
Receptors, Serotonin 4; Receptor, 5-
Hydroxytryptamine-
4; Receptor, 5-
HT4S; Receptor, 5-
HT4L; Receptor, 5-
HT4; 5 Hydroxytryptamine 4 Receptor; 5 HT4S Receptor; 5 HT4L Receptor; 5 HT4 Receptor; Serotonin 4 Receptors; Receptor, Serotonin 4; 5-
Hydroxytryptamine-
4 Receptor; 5-
HT4S Receptor; 5-
HT4L Receptor; 5-
HT4 Receptor; Serotonin 4 Receptor; Receptors, Serotonin, 5-
HT4S; Receptors, Serotonin, 5-
HT4L
Substance
CAS Registry & name
Categories
Source
Drugs
*
(1-
butylpiperidin-
4-
yl)methyl 4-
amino-
3-
methoxybenzoate
0
4-Aminobenzoic Acid/*analogs & derivatives
Carbon Radioisotopes
Ligands
Receptors, Serotonin, 5-HT4.
J Med Chem 2010 Oct 14;53(19):7035-47
CJ 033466
0
*Aminopyridines
*Imidazoles
Receptors, Serotonin, 5-HT4/agonists.
J Pharmacol Sci 2007 Oct;105(2):207-10
6,7-
dihydro-
4-
hydroxy-
7-
isopropyl-
6-
oxo-
N-
(3-
(piperidin-
1-
yl)propyl)thieno(2,3-
b)pyridine-
5-
carboxamide
0
*Pyridones
*Thiophenes
Receptors, Serotonin, 5-HT4/agonists.
Neuropharmacology 2007 Sep;53(4):563-73
ATI 7505
0
*Benzamides
*Quinuclidines
Receptors, Serotonin, 5-HT4/agonists.
Neurogastroenterol Motil 2007 Jan;19(1):30-8
hexahydro-
1H-
pyrrolizin-
1-
ylmethyl 1-
methyl-
1H-
indole-
3-
carboxylate
0
*Indoles
*Pyrrolizidine Alkaloids
Receptors, Serotonin, 5-HT4/antagonists & inhibitors.
J Med Chem 2006 Feb 9;49(3):1125-39
piboserod
152811-62-6
*Indoles
*Oxazines
Receptors, Serotonin, 5-HT4/antagonists & inhibitors.
Eur J Pharmacol 2003 Apr 25;467(1-3):211-8