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Receptor, Bradykinin B1

More information in Books or onNLM PubMed
Definition: A subtype of bradykinin receptor that is induced in response to INFLAMMATION. It may play a role in chronic inflammation and has a high specificity for KININS lacking the C-terminal ARGININE such as des-Arg(10)-kallidin and des-Arg(9)-bradykinin. The receptor is coupled to G-PROTEIN, GQ-G11 ALPHA FAMILY and G-PROTEIN, GI-GO ALPHA FAMILY signaling proteins.      Other names Receptors, Bradykinin B1; B1 Receptors, Bradykinin; B1 Receptor, Bradykinin; Bradykinin Type 1 Receptor; Bradykinin B1 Receptors; Bradykinin B1 Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4-bromo-5-((2-chlorobenzoyl)amino)-1-phenyl-N-(2-(1-(4-pyridinyl)-4-piperidinyl)ethyl)-1H-pyrazole-3-carboxamide  0   *Benzamides *Pyrazoles Receptor, Bradykinin B1/antagonists & inhibitors. J Med Chem 2007 Oct 18;50(21):5161-7
3-(4-fluorophenyl)-N-(7-(piperidin-1-ylmethyl)chroman-4-yl)-3-(3-(trifluoromethyl)phenylsulfonamido)propanamide  0   *Benzopyrans *Sulfonamides Receptor, Bradykinin B1/antagonists & inhibitors. J Med Chem 2007 May 3;50(9):2200-12
N-(2-(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)ethyl)-2-(3-oxo-1-(1,2,3,4-tetrahydroquinolin-8-ylsulfonyl)piperazin-2-yl)acetamide  0   *Acetamides *Sulfones Receptor, Bradykinin B1/antagonists & inhibitors. Biol Chem 2006 Feb;387(2):195-201
2-(3-oxo-1-(toluene-4-sulfonyl)-1,2,3,4-4H-quinoxalin-2-yl)-N-phenyl-acetamide  0   *Acetanilides *Tosyl Compounds Receptor, Bradykinin B2/antagonists & inhibitors Receptor, Bradykinin B1/antagonists & inhibitors. Biol Chem 2006 Feb;387(2):189-94
N-(2-(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)ethyl)-2-(1-(2-naphthylsulfonyl)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamide  0   *Quinoxalines *Sulfones Receptor, Bradykinin B1/antagonists & inhibitors. Biol Chem 2006 Feb;387(2):189-94
2-((3-(1,3-benzodioxol-5-yl)-3-(((6-methoxy-2-naphthyl)sulfonyl)amino)propanoyl)amino)-3-(4-((2,6-dimethylpiperidinyl)methyl)phenyl)-N-isopropyl-N-methylpropanamide  0   *Dioxoles *Sulfonamides Receptor, Bradykinin B1/antagonists & inhibitors. J Pharmacol Exp Ther 2004 May;309(2):661-9

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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