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Phosphodiesterase I

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Definition: A phosphoric diester hydrolase that removes 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated OLIGONUCLEOTIDES. It has low activity towards POLYNUCLEOTIDES and the presence of 3'-phosphate terminus on the substrate may inhibit hydrolysis.      Other names Phosphohydrolase, Orthophosphoric Diester; Phosphodiesterase, Alkaline; Phosphodiesterase I, Alkaline; Oligonucleate 5' Nucleotidohydrolase; Diester Phosphohydrolase, Orthophosphoric; 5' Nucleotidephosphodiesterase; 5' Exonuclease; Orthophosphoric Diester Phosphohydrolase; Oligonucleate 5'-Nucleotidohydrolase; Alkaline Phosphodiesterase I; Alkaline Phosphodiesterase; 5'-Nucleotidephosphodiesterase; 5'-Exonuclease
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
scolochinenoside C  0   *Glucosides *Hydroquinones Phosphodiesterase I/antagonists & inhibitors. Planta Med 2010 Mar;76(4):358-61
phosphodiesterase I, snake venom  EC 3.1.4.1   *Phosphodiesterase I Snake Venoms.
KF 19514  0   *Naphthyridines Phosphodiesterase I/antagonists & inhibitors. Eur J Pharmacol 1997 May 26;327(1):57-63

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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