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Receptors, Eph Family

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Definition: A large family of receptor protein-tyrosine kinases that are structurally-related. The name of this family of proteins derives from original protein Eph (now called the EPHA1 RECEPTOR), which was named after the cell line it was first discovered in: Erythropoietin-Producing human Hepatocellular carcinoma cell line. Members of this family have been implicated in regulation of cell-cell interactions involved in nervous system patterning and development.     
Examples Receptor, EphA1; Receptor, EphA2; Receptor, EphA3; Receptor, EphA4; Receptor, EphA5; Receptor, EphA6; Receptor, EphA7; Receptor, EphA8; Receptor, EphB1; Receptor, EphB2; Receptor, EphB3; Receptor, EphB4; Receptor, EphB5 		Other names Receptors, Ephrin A; Receptors, Ephrin; Receptors, EphB; Receptors, Eph; Receptor, Ephrin B; Ephrin Receptors; Ephrin B Receptors; Ephrin B Receptor; Ephrin A Receptors; EphB Receptors; EphB Receptor; EphA Receptors; Eph Receptors; Eph Receptor Tyrosine Kinase; Eph Family Receptors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
EPHA10 protein, human  0   *Receptors, Eph Family. Cancer Genomics Proteomics. 2011 Jul-Aug;8(4):185-93.
rtk8 protein, zebrafish  EC 2.7.1.112   *Zebrafish Proteins *Receptors, Eph Family.
Dek protein, Drosophila  EC 2.7.11.-   *Drosophila Proteins *Receptors, Eph Family. Mol Cell Neurosci 1999 May;13(5):337-47
ek1 protein, zebrafish  EC 2.7.1.-   *Zebrafish Proteins *Receptors, Eph Family. Dev Dyn 1997 Jun;209(2):166-81
PL7a protein, Xenopus  EC 2.7.1.112   *Xenopus Proteins *Receptors, Eph Family. Oncogene 1995 Nov 2;11(9):1745-52

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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