encyclopedia of medical concepts
ψ 
ψ 
ψ 

RNA, Small Interfering

More information in Books or onNLM PubMed
Definition: Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.  Do not confuse with defective interfering RNA (diRNA), a viral RNA of DEFECTIVE VIRUSES.   
See Also MicroRNAs; RNA Interference; RNA-Induced Silencing Complex 		Other names siRNA, Trans Acting; siRNA, Repeat Associated; Trans Acting siRNA; Repeat Associated siRNA; RNA, Small Scan; RNA, Small Hairpin; Scan RNA, Small; RNA, Short Interfering; RNA, Short Hairpin; RNA, Piwi Interacting; Piwi Interacting RNA; Interfering RNA, Small; Interfering RNA, Short; Hairpin RNA, Small; Hairpin RNA, Short; tasiRNA; shRNA; scnRNA; piRNA; Small Interfering RNA
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Atu027  0   *RNA, Small Interfering. Cancer Res 2008 Dec 1;68(23):9788-98
bevasiranib  0   *RNA, Small Interfering. Mol Vis 2008 May 28;14:997-1005
MPG-8 peptide  0   *Oligopeptides *RNA-Binding Proteins RNA, Small Interfering Nanoparticles. Nucleic Acids Res. 2009 Aug;37(14):4559-69
ISIS 121736  0   *RNA, Small Interfering. Nucleic Acids Res 2008 Mar;36(4):1081-97

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy