Definition: A multifunctional heterogeneous-nuclear ribonucleoprotein that may play a role in homologous DNA pairing and recombination. The N-terminal portion of protein is a potent transcriptional activator, while the C terminus is required for RNA binding. The name FUS refers to the fact that genetic recombination events result in fusion oncogene proteins (ONCOGENE PROTEINS, FUSION) that contain the N-terminal region of this protein. These fusion proteins have been found in myxoid liposarcoma (LIPOSARCOMA, MYXOID) and acute myeloid leukemia.
Other names RNA-Binding Protein, FUS; RNA Binding Protein FUS; FUS RNA Binding Protein; hnRNP P2; Translocated in Liposarcoma Protein; TLS Protein; POMp75 Protein; Fusion Protein in Myxoid Liposarcoma; FUS Protein; FUS RNA-Binding Protein
