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Epothilones

More information in Books or onNLM PubMed
Definition: A group of 16-member MACROLIDES which stabilize MICROTUBULES in a manner similar to PACLITAXEL. They were originally found in the myxobacterium Sorangium cellulosum, now renamed to Polyangium (MYXOCOCCALES).     
Pharmacological Action Tubulin Modulators 		Other names Epothilone; Epothilon
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
KOS-1584  0   *Epothilones Antineoplastic Agents. Cancer Chemother Pharmacol. 2012 Feb;69(2):523-31
12,13-cyclopropyl-epothilone B  0   *Epothilones. Org Lett. 2011 Mar 18;13(6):1436-9
C26-hydroxyepothilone D  0   *Epothilones. J Org Chem. 2010 Jan 1;75(1):86-94
10,14-dihydroxy-9,11,13,13-tetramethyl-2-(1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl)-5-(7-nitro-benzo(1,2,5)oxadiazol-4-yl)-1-oxa-5-aza-cyclohexadecane-12,16-dione  0   *Epothilones 4-Chloro-7-nitrobenzofurazan/*analogs & derivatives. Chembiochem 2009 Oct 12;10(15):2513-21
(S)-14-methoxyepothilone  0   *Epothilones. Org Lett. 2009 Aug 6;11(15):3186-9
AV-EPO-106  0   *Epothilones. Biomed Chromatogr. 2009 Mar;23(3):302-7
sagopilone  0   *Epothilones *Benzothiazoles. Cancer Res 2008 Jul 1;68(13):5301-8
cryptothilone 1  0   *Epothilones. Org Lett 2006 Aug 31;8(18):3947-50
fludelone  0   *Epothilones. Cancer Res. 2005 Oct 15;65(20):9445-54
26-trifluoro-(E)-9,10-dehydro-12,13-desoxyepothilone B  0   *Epothilones. J Am Chem Soc. 2004 Sep 8;126(35):10913-22
BMS 310705  0   *Epothilones. Gynecol Oncol. 2003 Oct;91(1):173-8
epothilone 490  0   *Thiazoles *Epothilones. J Am Chem Soc 2002 Aug 21;124(33):9825-32
10,11-didehydroepothilone D  0   *Thiazoles *Epothilones. J Nat Prod 2002 Jul;65(7):1061-4
9,10-dehydroepothilone D  0   *Epothilones. J Am Chem Soc 2001 Jun 13;123(23):5407-13
epothilone I  0   *Epothilones. J Nat Prod 2001 Jul;64(7):847-56
epothilone K  0   *Epothilones. J Nat Prod 2001 Jul;64(7):847-56
ixabepilone  219989-84-1   *Epothilones Tubulin Modulators. Clin Cancer Res 2001 May;7(5):1429-37IXEMPRA KIT
epothilone F  0   *Epothilones. Chemistry 2001 Apr 17;7(8):1691-702
epothilone C  0   *Epothilones. Chemistry 2001 Apr 17;7(8):1691-702
epothilone C-D monooxygenase  EC 1.13.12.-   *Oxygenases Epothilones. J Antibiot (Tokyo) 2001 Feb;54(2):144-8
12,13-desoxyepothilone F  0   *Epothilones. J Org Chem 2000 Oct 6;65(20):6525-33
15-aza-12,13-desoxyepothilone B  0   *Epothilones. Org Lett 2000 Jan 1;2(11):1637-9
epothilone E  0   *Epothilones. Bioorg Med Chem1999 May;7(5):665-97
desoxyepothilone B  0   *Epothilones Tubulin Modulators. Proc Natl Acad Sci U S A 1998 Aug 4;95(16):9642-7
C12,13-cyclopropylepothilone A  0   *Epothilones. Chem Biol 1998 Jul;5(7):365-72
desoxyepothilone A  0   *Epothilones. Proc Natl Acad Sci U S A 1998 Feb 17;95(4):1369-74
epothilone B  0   *Epothilones.
Pharma Action Antineoplastic Agents ; Tubulin Modulators 		Cancer Res 1995 Jun 1;55(11):2325-33
epothilone A  0   *Epothilones.
Pharma Action Antineoplastic Agents ; Tubulin Modulators 		Cancer Res 1995 Jun 1;55(11):2325-33

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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