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Peptide Elongation Factor 1

More information in Books or onNLM PubMed
Definition: Peptide elongation factor 1 is a multisubunit protein that is responsible for the GTP-dependent binding of aminoacyl-tRNAs to eukaryotic ribosomes. The alpha subunit (EF-1alpha) binds aminoacyl-tRNA and transfers it to the ribosome in a process linked to GTP hydrolysis. The beta and delta subunits (EF-1beta, EF-1delta) are involved in exchanging GDP for GTP. The gamma subunit (EF-1gamma) is a structural component.      Other names EF 1; EF 1gamma; EF 1delta; EF 1beta; EF 1alpha; EF 1H; 1, EF; EF-1gamma; EF-1delta; EF-1beta; EF-1H; EF-1alpha; Elongation Factor 1gamma; Elongation Factor 1delta; Elongation Factor 1beta; Elongation Factor 1alpha; Elongation Factor 1; EF-1
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
XEF1AO protein, Xenopus  0   *Peptide Elongation Factor 1 *Xenopus Proteins. Biochem J 2007 Aug 1;405(3):495-501
NSC 4347  0   *Benzhydryl Compounds *Phenylacetates Peptide Elongation Factor 1/antagonists & inhibitors. Proteins 2007 Apr 1;67(1):53-64
NSC 36398  0   *Catechols *Chromones Peptide Elongation Factor 1/antagonists & inhibitors. Proteins 2007 Apr 1;67(1):53-64
NSC 122281  0   *Naphthalenes *Sulfonamides Peptide Elongation Factor 1/antagonists & inhibitors. Proteins 2007 Apr 1;67(1):53-64
Eef1a2 protein, rat  0   *Peptide Elongation Factor 1.
Eef1a2 protein, mouse  0   *Peptide Elongation Factor 1.
EEF1A2 protein, human  0   *Peptide Elongation Factor 1.
TEF1 protein, S cerevisiae  0   *Peptide Elongation Factor 1 *Saccharomyces cerevisiae Proteins. Gene 2000 May 16;249(1-2):145-51
EEF1A1 protein, human  0   *Peptide Elongation Factor 1 Tumor Markers, Biological. Proc Natl Acad Sci U S A 1995 Jul 18;92(15):6778-82
CAM1 protein, S cerevisiae  0   *Peptide Elongation Factor 1 *Saccharomyces cerevisiae Proteins. Yeast 1993 Feb;9(2):151-63

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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