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Monomeric GTP-Binding Proteins

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Definition: A class of monomeric, low molecular weight (20-25 kDa) GTP-binding proteins that regulate a variety of intracellular processes. The GTP bound form of the protein is active and limited by its inherent GTPase activity, which is controlled by an array of GTPase activators, GDP dissociation inhibitors, and guanine nucleotide exchange factors. This enzyme was formerly listed as EC 3.6.1.47     
Examples ADP-Ribosylation Factors; rab GTP-Binding Proteins; ral GTP-Binding Proteins; ran GTP-Binding Protein; rap GTP-Binding Proteins; ras Proteins; rho GTP-Binding Proteins 		Other names ras Related GTPases; ras Related GTP Binding Proteins; ras Related G Proteins; Small G Proteins; Proteins, ras-Related GTP-Binding; Monomeric GTP Binding Proteins; Monomeric G Proteins; GTPases, ras-Related; GTPases, Small; GTP-Binding Proteins, ras-Related; GTP Binding Proteins, Monomeric; G-Proteins, ras-Related; G-Proteins, Small; G Proteins, Monomeric; ras-Related GTP-Binding Proteins; ras-Related G-Proteins; ras-Related GTPases; Small GTPases; Monomeric G-Proteins; GTP-Binding Proteins, Monomeric
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Rem1 protein, rat  0   *Monomeric GTP-Binding Proteins. Circ Res. 2012 Jan 6;110(1):59-70
Cdc42 protein, Xenopus  EC 3.6.5.2   *Monomeric GTP-Binding Proteins *Xenopus Proteins Cell Cycle Proteins. J Biol Chem 2000 Jan 28;275(4):2367-75
Ras-dva-2 protein, Xenopus  EC 3.6.5.2   *Monomeric GTP-Binding Proteins *Xenopus Proteins. Gene Expr Patterns 2011 Jan-Feb;11(1-2):156-61
ARL-3 protein, C elegans  EC 3.6.5.2   *Monomeric GTP-Binding Proteins *Caenorhabditis elegans Proteins. J Cell Biol 2010 Jun 14;189(6):1039-51
ARL-13 protein, C elegans  EC 3.6.5.2   *Monomeric GTP-Binding Proteins *Caenorhabditis elegans Proteins. J Cell Biol 2010 Jun 14;189(6):1039-51
RhoA protein, zebrafish  EC 3.6.5.2   *Monomeric GTP-Binding Proteins *Zebrafish Proteins. Dev Biol 2010 Apr 15;340(2):626-39
RASL11A protein, mouse  EC 3.6.1.-   *Monomeric GTP-Binding Proteins. EMBO J. 2010 Apr 7;29(7):1215-24
Rab30 protein, Drosophila  EC 3.6.5.2   *Monomeric GTP-Binding Proteins *Drosophila Proteins. Dev Biol 2009 Jul 15;331(2):250-60
SGP2 protein, Arabidopsis  EC 3.6.5.2   *Monomeric GTP-Binding Proteins *Arabidopsis Proteins. Int J Dev Biol 2009;53(1):177-85
SGP1 protein, Arabidopsis  EC 3.6.5.2   *Monomeric GTP-Binding Proteins *Arabidopsis Proteins. Int J Dev Biol 2009;53(1):177-85
RHEB-1 protein, C elegans  EC 3.6.5.2   *Monomeric GTP-Binding Proteins *Caenorhabditis elegans Proteins. Nature. 2009 Feb 5;457(7230):726-30
Sar1 protein, Drosophila  EC 3.6.1.-   *Monomeric GTP-Binding Proteins *Drosophila Proteins. Mol Biol Cell 2008 Oct;19(10):4352-65
RabD1 protein, Arabidopsis  EC 3.6.1.-   *Monomeric GTP-Binding Proteins *Arabidopsis Proteins. J Exp Bot 2008;59(13):3523-31
RalA protein, Drosophila  EC 3.6.5.2   *Monomeric GTP-Binding Proteins *Drosophila Proteins. EMBO Rep 2008 Jul;9(7):676-82
Rheb protein, S pombe  EC 3.6.5.2   *Monomeric GTP-Binding Proteins. J Biol Chem 2000 Apr 14;275(15):11198-206
REM2 protein, human  EC 3.6.1.47   *Monomeric GTP-Binding Proteins. J Biol Chem 2008 Feb 15;283(7):4408-16
Arl3 protein, Drosophila  EC 3.6.5.2   *Monomeric GTP-Binding Proteins *Drosophila Proteins. Mech Dev 2008 Mar-Apr;125(3-4):325-36
LIP1 small GTPase, Arabidopsis  EC 3.6.5.2   *Monomeric GTP-Binding Proteins *Arabidopsis Proteins. Curr Biol 2007 Sep 4;17(17):1456-64
RASL11B protein, human  EC 3.6.5.2   *Monomeric GTP-Binding Proteins. Biochim Biophys Acta 2007 Jul-Aug;1769(7-8):514-24
RASSF6 protein, human  0   *Monomeric GTP-Binding Proteins. Exp Cell Res 2007 Apr 15;313(7):1484-95
ROP6 protein, Arabidopsis  0   *Monomeric GTP-Binding Proteins *Arabidopsis Proteins. Mol Cell Biol 2007 Mar;27(6):2144-54
Rem2 protein, mouse  EC 3.6.1.47   *Monomeric GTP-Binding Proteins. Arch Biochem Biophys 1999 Aug 15;368(2):401-12
GTPBP10 protein, human  EC 3.6.5.2   *Monomeric GTP-Binding Proteins. Genes Cells 2006 Nov;11(11):1295-304
GTPBP5 protein, human  EC 3.6.5.2   *Monomeric GTP-Binding Proteins. Genes Cells 2006 Nov;11(11):1295-304
SAR1B protein, human  EC 3.6.1.-   *Monomeric GTP-Binding Proteins.
ROP9 protein, Arabidopsis  EC 3.6.1.47   *Monomeric GTP-Binding Proteins *Arabidopsis Proteins Membrane Proteins. Plant J 2006 Jun;46(6):934-47
Ras-dva protein, Xenopus  EC 3.6.5.2   *Monomeric GTP-Binding Proteins *Xenopus Proteins. Development 2006 Feb;133(3):485-94
RAC2 protein, Arabidopsis  EC 3.6.1.47   *Monomeric GTP-Binding Proteins *Arabidopsis Proteins. J Exp Bot 2005 Sep;56(419):2465-76
YPT6 protein, S cerevisiae  EC 3.6.5.2   *Monomeric GTP-Binding Proteins *Saccharomyces cerevisiae Proteins.
SAR1A protein, human  EC 3.6.1.-   *Monomeric GTP-Binding Proteins. Curr Opin Lipidol 2004 Apr;15(2):191-7
Mras protein, rat  EC 3.6.1.-   *Monomeric GTP-Binding Proteins Cytoskeletal Proteins.
ObgE protein, E coli  EC 3.6.1.-   *Monomeric GTP-Binding Proteins *Escherichia coli Proteins.
GEM protein, human  EC 3.6.5.2   *Monomeric GTP-Binding Proteins.
Rheb protein, mouse  0   *Neuropeptides *Monomeric GTP-Binding Proteins Growth Substances.
Rheb protein, Drosophila  0   *Neuropeptides *Monomeric GTP-Binding Proteins *Drosophila Proteins.
RHEB protein, human  0   *Neuropeptides *Monomeric GTP-Binding Proteins.
Rras2 protein, mouse  EC 3.6.1   *Membrane Proteins *Monomeric GTP-Binding Proteins Genes, ras.
CIN4 protein, S cerevisiae  EC 3.6.1.-.   *Monomeric GTP-Binding Proteins *Saccharomyces cerevisiae Proteins.
SAR1 protein, rat  EC 3.6.1.-   *Monomeric GTP-Binding Proteins. J Cell Biol 1994 Apr;125(1)51-65.
ARL1 protein, S cerevisiae  EC 3.6.1.-   *Monomeric GTP-Binding Proteins *Saccharomyces cerevisiae Proteins *Vesicular Transport Proteins. Nat Cell Biol. 2004 May;6(5):403-13
RASL11A protein, human  EC 3.6.1.-   *Monomeric GTP-Binding Proteins. Biochem Biophys Res Commun 2004 Apr 9;316(3):618-27
Rem2 protein, rat  EC 3.6.5.2   *Monomeric GTP-Binding Proteins.
Gtpbp1 protein, mouse  0   *Monomeric GTP-Binding Proteins.
RRAGB protein, human  EC 3.6.1.-   *Monomeric GTP-Binding Proteins.
RRAGA protein, human  EC 3.6.1.-   *Monomeric GTP-Binding Proteins.
Samhd1 protein, mouse  0   *Monomeric GTP-Binding Proteins.
SAMHD1 protein, human  0   *Monomeric GTP-Binding Proteins.
Rassf3 protein, mouse  0   *Monomeric GTP-Binding Proteins Genes, Tumor Suppressor. Oncogene 2002 Apr 18;21(17):2713-20
RASSF5 protein, human  0   *Monomeric GTP-Binding Proteins Genes, Tumor Suppressor Apoptosis. Oncogene 2002 Apr 18;21(17):2713-20
RASSF3 protein, human  0   *Monomeric GTP-Binding Proteins Genes, Tumor Suppressor. Oncogene 2002 Apr 18;21(17):2713-20
RRAGD protein, human  0   *Monomeric GTP-Binding Proteins. J Biol Chem 2001 Mar 9;276(10):7246-57
RRAGC protein, human  0   *Monomeric GTP-Binding Proteins. J Biol Chem 2001 Mar 9;276(10):7246-57
Agap2 protein, rat  EC 3.6.1.-   *Monomeric GTP-Binding Proteins. Cell 2000 Dec 8;103(6):919-30
GTPBP2 protein, human  EC 3.6.1.-   *Monomeric GTP-Binding Proteins. Biochem Biophys Res Commun 2000 Jun 7;272(2):456-65
GTR2 protein, S cerevisiae  0   *Monomeric GTP-Binding Proteins *Saccharomyces cerevisiae Proteins. Genetics 1999 Jul;152(3):853-67
Gtr1 protein, S cerevisiae  0   *Monomeric GTP-Binding Proteins *Saccharomyces cerevisiae Proteins. Mol Cell Biol 1992 Jul;12(7):2958-66
Sbp1 protein, S pombe  0   *Monomeric GTP-Binding Proteins *Schizosaccharomyces pombe Proteins. Genetics 1998 Feb;148(2):645-56
Mras protein, mouse  EC 3.6.1.-   *Monomeric GTP-Binding Proteins Cytoskeletal Proteins. Oncogene 1997 Nov 13;15(20):2409-17
CgtA protein, bacteria  EC 3.6.1.-   *Bacterial Proteins *Monomeric GTP-Binding Proteins. J Bacteriol 1997 Oct;179(20):6426-31
Rem protein, mouse  0   *Monomeric GTP-Binding Proteins. J Biol Chem 1997 Aug 29;272(35):21982-8
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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