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Caspases

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Definition: A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.  CASPASES, EFFECTOR and CASPASES, INITIATOR and specifics are available   
See Also Apoptosis
Examples Caspases, Effector; Caspases, Initiator
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
caspase 32, rat  EC 3.4.22.-   *Caspases. Endocr Regul. 2010 Jul;44(3):83-8
MC2 protein, Arabidopsis  EC 3.4.22.-   *Caspases *Arabidopsis Proteins. Science 2010 Dec 3;330(6009):1400-4
MC1 protein, Arabidopsis  EC 3.4.22.-   *Caspases *Arabidopsis Proteins. Science 2010 Dec 3;330(6009):1393-7
metacaspase 9, Arabidopsis  EC 3.4.22.-   *Caspases *Arabidopsis Proteins. J Biol Chem 2004 Oct 29;279(44):45329-36
caspase 9s, human  0   *Caspases. J Biol Chem 1999 Jan 22;274(4):2072-6
Casp14 protein, mouse  EC 3.4.22.-   *Caspases.
CASP14 protein, human  EC 3.4.22.-   *Caspases.
Malt1 protein, mouse  0   *Neoplasm Proteins *Caspases.
Nol3 protein, rat  0   *Muscle Proteins *Apoptosis Regulatory Proteins Apoptosis Caspases.
Nol3 protein, mouse  0   *Muscle Proteins *Apoptosis Regulatory Proteins Apoptosis Caspases.
Casp11 protein, rat  EC 3.4.22.-   *Caspases Inflammation Apoptosis.
z-Val-Ala-Asp(Ome)-fluoromethylketone  0   *Amino Acid Chloromethyl Ketones Caspases/antagonists & inhibitors. J Neurosci 2003 Jul 9;23(14):6111-22
caspy protein, zebrafish  EC 3.4.22.-   *Caspases *Zebrafish Proteins. J Biol Chem 2003 Feb 7;278(6):4268-76
MCA1 protein, S cerevisiae  EC 3.4.22.-   *Caspases *Saccharomyces cerevisiae Proteins. Mol Cell 2002 Apr;9(4):911-7
3,4-methylenedioxyphenyl 3,4,5--trihydroxythiobenzoate  0   *Dioxoles Gallic Acid/*analogs & derivatives Caspases/agonists. Biol Pharm Bull 2001 Jul;24(7):
3,4-methylenedioxyphenyl 3,4,5-trihydroxybenzoate  0   *Dioxoles Gallic Acid/*analogs & derivatives Caspases/agonists. Biol Pharm Bull 2001 Jul;24(7):844-7
dream protein, Drosophila  EC 3.4.22.-   *Caspases *Drosophila Proteins. Cell Death Differ 2001 Apr;8(4):387-94
DAMM protein, Drosophila  EC 3.4.22.-   *Caspases *Drosophila Proteins. J Biol Chem 2001 Jul 6;276(27):25342-50
dredd protein, Drosophila  EC 3.4.22.-   *Caspases *Drosophila Proteins. Trends Immunol 2001 May;22(5):260-4
BIRC8 protein, human  0   *Inhibitor of Apoptosis Proteins Apoptosis Caspases/antagonists & inhibitors. Mol Cell Biol 2001 Jul;21(13):4292-301
acetyl-aspartyl-glutamyl-valyl-lysine chloromethyl ketone  0   *Amino Acid Chloromethyl Ketones Caspases/antagonists & inhibitors. J Neurosci Res 2001 Apr 15;64(2):183-92
acetyl-AAVALLPAVLLALLAP-DEVD-CHO  0   *Peptides Caspases/antagonists & inhibitors. J Neurosci Res 2001 Apr 15;64(2):183-92
acetyl-AAVALLPAVLLALLAP-YVAD-CHO  0   *Peptides Caspases/antagonists & inhibitors. J Neurosci Res 2001 Apr 15;64(2):183-92
benzyloxycarbonyl-valyl-alanyl-(methyl)aspartic acid fluoromethyl ketone  0   *Amino Acid Chloromethyl Ketones Caspases/antagonists & inhibitors. Transplantation 2001 Apr 15;71(7):1007-11
Z-Asp-2,6-dichlorobenzoyl-oxymethylketone  0   *Amino Acid Chloromethyl Ketones Caspases/antagonists & inhibitors. Transpl Int 2000 ;13 Suppl 1:S568-72
acetyl-leucyl-glutamyl-histidyl-aspartal  0   *Oligopeptides Caspases/antagonists & inhibitors. Cancer Res 2000 Dec 15;60(24):6811-7
Xyz 033 mp  0   *Benzene Derivatives Caspases/antagonists & inhibitors. Clin Immunol. 2000 Dec;97(3):221-33
CV 1013  0   *Organic Chemicals Caspases/antagonists & inhibitors. Toxicol Appl Pharmacol 2000 Nov 15;169(1):77-83
benzyloxycarbonyl-aspartyl(O-methyl)fluoromethane  0   Aspartic Acid/*analogs & derivatives Caspases/antagonists & inhibitors. J Cell Biol 2000 Aug 21;150(4):741-54
decay protein, Drosophila  EC 3.4.22.-   *Caspases *Drosophila Proteins. J Biol Chem 1999 Oct 22;274(43):30778-83
MALT1 protein, human  EC 3.4.22.-   *Neoplasm Proteins *Caspases Lung Neoplasms Lymphoma, B-Cell, Marginal Zone. Blood 1999 Jun 1;93(11):3601-9; Oncogene 1999 Oct 14;18(42):5785-94
benzyloxycarbonyl aspartyl-glutamyl-valyl-aspartyl-chloromethyl ketone  0   *Oligopeptides Caspases/antagonists & inhibitors. Exp Neurol 1999 Jul;158(1):202-5
aposome  0   *Multienzyme Complexes Caspases. J Biol Chem 1999 Aug 6;274(32):22686-92
IDN 1965  0   *Indoles *Oligopeptides Caspases/antagonists & inhibitors. Methods 1999 Apr;17(4):320-8
IDN 1529  0   *Indoles *Oligopeptides Caspases/antagonists & inhibitors. Methods 1999 Apr;17(4):320-8
Nc protein, Drosophila  EC 3.4.22.-   *Caspases *Drosophila Proteins Apoptosis. Proc Natl Acad Sci U S A 1999 Apr 13;96(8):4307-12
tyrosyl-valyl-alanyl-aspartal  0   *Oligopeptides Caspases/antagonists & inhibitors. J Cell Biol 1999 Apr 5;145(1):99-108
csp-3 protein, C elegans  EC 3.4.22.-   *Caspases *Caenorhabditis elegans Proteins Apoptosis. J Biol Chem 1998 Dec 25;273(52):35109-17
csp-1 protein, C elegans  EC 3.4.22.-   *Caspases *Caenorhabditis elegans Proteins Apoptosis. J Biol Chem 1998 Dec 25;273(52):35109-17
caspase 13  EC 3.4.22.-   *Caspases. J Biol Chem 1998 Jun 19;273(25):15702-7
NOL3 protein, human  0   *Muscle Proteins *Apoptosis Regulatory Proteins Apoptosis Caspases/antagonists & inhibitors. J Biol Chem 1999 Apr 16;274(16):10951-62; Proc Natl Acad Sci U S A 1998 Apr 28;95(9):5156-60
Ice protein, Drosophila  EC 3.4.22.-   *Caspases *Drosophila Proteins Apoptosis. EMBO J 1997 Oct 15;16(20):6192-9
Dcp-1 protein, Drosophila  EC 3.4.22.-   *Caspases *Drosophila Proteins. Science 1997 Jan 24;275(5299):536-40
butyloxycarbonyl-O-methyl-aspartyl-fluoromethyl ketone  0   *Amino Acid Chloromethyl Ketones Caspases/antagonists & inhibitors.
Pharma Action Cysteine Proteinase Inhibitors 		J Exp Med 1996 Dec 1;184(6):2445-50
Casp11 protein, mouse  EC 3.4.22.-   *Caspases Inflammation Apoptosis. J Biol Chem 1996 Aug 23;271(34):20580-7
CASP5 protein, human  EC 3.4.22.-   *Caspases Apoptosis. Eur J Biochem 1996 Feb 15;236(1):207-13
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone  0   *Amino Acid Chloromethyl Ketones Caspases/antagonists & inhibitors.
Pharma Action Cysteine Proteinase Inhibitors ; Neuroprotective Agents 		FEBS Lett 1995 Oct 30;374(2):303-8
ced-3 protein, C elegans  EC 3.4.22.-   *Caspases *Caenorhabditis elegans Proteins Apoptosis. Bioassays 1994 Jun;16(6):387-9

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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