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Peptide Nucleic Acids

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Definition: DNA analogs containing neutral amide backbone linkages composed of aminoethyl glycine units instead of the usual phosphodiester linkage of deoxyribose groups. Peptide nucleic acids have high biological stability and higher affinity for complementary DNA or RNA sequences than analogous DNA oligomers.      Other names Nucleic Acids, Peptide; Acids, Peptide Nucleic
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Rpep-PNA-a210  0   *Peptide Nucleic Acids. ChemMedChem. 2011 Dec 9;6(12):2192-202.
aminoethylglycyl PNA  0   *Peptide Nucleic Acids Glycine/*analogs & derivatives. Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1307-10
PNAEmu-NLS  0   *Peptide Nucleic Acids Nuclear Localization Signals. Mutat Res 2007 Apr 2;628(2):129-37
12-(3,5-diamino-2-O-(2,6-diamino-2,6-dideoxyglucopyranosyl)-6-hydroxycyclohexyloxy)-1,6-diaza-2,5-dioxododecanyl-TCCCAGGCTCAGATCT-carboxamide  0   *Peptide Nucleic Acids. J Med Chem 2004 Sep 23;47(20):4806-9
ISIS 208529  0   *Peptide Nucleic Acids. Nucleic Acids Res 2004;32(9):2695-706
Product R  0   *Peptide Nucleic Acids HIV. HIV Clin Trials 2002 Jul-Aug;3(4):272-8
dexamethasone-bis-peptide nucleic acid  0   *Dexamethasone *Peptide Nucleic Acids. FASEB J 2002 Sep;16(11):1426-8
peptide nucleic acid, T10-lysine  139166-85-1   *Peptide Nucleic Acids Oligonucleotides, Antisense. Science 1992 Nov 27;258(5087):1481-5
reticulose  0   *Peptide Nucleic Acids. J R Soc Health 1991 Oct;111(5):170-1

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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