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O(6)-Methylguanine-DNA Methyltransferase

More information in Books or onNLM PubMed
Definition: An enzyme that transfers methyl groups from O(6)-methylguanine, and other methylated moieties of DNA, to a cysteine residue in itself, thus repairing alkylated DNA in a single-step reaction. EC 2.1.1.63.      Other names S-Methyltransferase, Methylated-DNA-Protein-Cystei; Methylated DNA Protein Cysteine S Methyltransferas; O(6)-Methylguanine DNA Transmethylase; O(6)-MeG-DNA Methyltransferase; O(6)-Alkylguanine-DNA Alkyltransferase; Guanine-O(6)-Alkyltransferase; DNA Repair Methyltransferase II; DNA Repair Methyltransferase I; O(6)-Methylguanine Methyltransferase; O(6)-AGT; Methylated-DNA-Protein-Cysteine S-Methyltransferas
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
O(4)-benzylfolic acid  0   Folic Acid/*analogs & derivatives O(6)-Methylguanine-DNA Methyltransferase/antagonists & inhibitors. Cancer Chemother Pharmacol 2007 Nov;60(6):883-9
O(6)-(5-iodobenzyl)guanine  0   Guanine/*analogs & derivatives Iodine Radioisotopes O(6)-Methylguanine-DNA Methyltransferase/antagonists & inhibitors. J Med Chem 2006 Jan 12;49(1):263-72
O(6)-(5-iodothenyl)guanine  0   Guanine/*analogs & derivatives Iodine Radioisotopes O(6)-Methylguanine-DNA Methyltransferase/antagonists & inhibitors. J Med Chem 2006 Jan 12;49(1):263-72
6-benzyloxy-7-(2-fluoroethyl)-7H-purine-2-yl-amine  0   *Purines Fluorine Radioisotopes O(6)-Methylguanine-DNA Methyltransferase/antagonists & inhibitors. Appl Radiat Isot 2002 Mar;56(3):511-7
6-benzyloxy-9-(2-fluoroethyl)-9H-purin-2-yl-amine  0   *Purines Fluorine Radioisotopes O(6)-Methylguanine-DNA Methyltransferase/antagonists & inhibitors. Appl Radiat Isot 2002 Mar;56(3):511-7
O(6)-(1-cyclopentenylmethyl)guanine  0   Guanine/*analogs & derivatives O(6)-Methylguanine-DNA Methyltransferase/antagonists & inhibitors. J Med Chem 2000 Nov 2;43(22):4071-83
Ada protein, E coli  EC 2.1.1.63   *Transcription Factors *O(6)-Methylguanine-DNA Methyltransferase *Escherichia coli Proteins. J Biol Chem 1985;260(12):7281

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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