Definition: An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include alcohol; NITROSAMINES; BENZENE; URETHANE; and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.
do not confuse with other cytochrome P-450 CYP's
Other names N Nitrosodimethylamine Demethylase; Dimethylnitrosamine N Demethylase; Cytochrome P 450 J; Cytochrome P 450 IIE1; Cytochrome P 450 CYP2E1; 4 Nitrophenol 2 Hydroxylase; N-Nitrosodimethylamine Demethylase; Cytochrome P450 2E1; Cytochrome P-450-J; Cytochrome P-450 IIE1; Cytochrome P-450 (ALC); CYPIIE1; CYP IIE1; CYP 2E1; Dimethylnitrosamine N-Demethylase; CYP2E1; 4-Nitrophenol-2-Hydroxylase