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Thapsigargin

More information in Books or onNLM PubMed
Definition: A sesquiterpene lactone found in roots of THAPSIA. It inhibits CA(2+)-TRANSPORTING ATPASE mediated uptake of CALCIUM into SARCOPLASMIC RETICULUM.     
Pharmacological Action Enzyme Inhibitors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
L12ADT  0   Thapsigargin/*analogs & derivatives. J Natl Cancer Inst 2003 Jul 2;95(13):990-1000
8-O-(12-(leucinoylamino)dodecanoyl)-8-O-debutanoylthapsigargin  0   Thapsigargin/*analogs & derivatives. J Med Chem 2001 Dec 20;44(26):4696-703
8-O-(4-(4-aminophenyl)butanoyl)-8-O-debutanoylthapsigargin  0   Thapsigargin/*analogs & derivatives Calcium-Transporting ATPases/antagonists & inhibitors. Bioorg Med Chem 1999 Jul;7(7):1273-80
8-O-(3-(4-aminophenyl)propionyl)-8-O-debutanoylthapsigargin  0   Thapsigargin/*analogs & derivatives Calcium-Transporting ATPases/antagonists & inhibitors. Bioorg Med Chem 1999 Jul;7(7):1273-80
8-O-(4-aminocinnamoyl)-8-O-debutanoylthapsigargin  0   Thapsigargin/*analogs & derivatives. FEBS Lett 1998 Nov 13;439(1-2):127-32
eosinthapsigargin  0   Eosine Yellowish-(YS)/*analogs & derivatives Thapsigargin/*analogs & derivatives Calcium-Transporting ATPases/antagonists & inhibitors Lactones. Biochemistry 1995 Apr 18;34(15):5137-42
dansylthapsigargin  0   *Dansyl Compounds Thapsigargin/*analogs & derivatives Calcium-Transporting ATPases/antagonists & inhibitors Lactones. Biochemistry 1995 Apr 18;34(15):5137-42

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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