Definition: Autoantibodies directed against cytoplasmic constituents of POLYMORPHONUCLEAR LEUKOCYTES and/or MONOCYTES. They are used as specific markers for WEGENER GRANULOMATOSIS and other diseases, though their pathophysiological role is not clear. ANCA are routinely detected by indirect immunofluorescence with three different patterns: c-ANCA (cytoplasmic), p-ANCA (perinuclear), and atypical ANCA.
do not coordinate with ANTIBODY FORMATION for /biosyn;
Pharmacological ActionImmunologic Factors
Other names p ANCA; c ANCA; Cytoplasmic Antibody, Antineutrophil; Cytoplasmic Antibody, Anti-Neutrophil; Cytoplasmic Antibodies, Antineutrophil; Cytoplasmic Antibodies, Anti-Neutrophil; Antibody, Antineutrophil Cytoplasmic; Antibody, Anti-Neutrophil Cytoplasmic; Antibodies, Anti-Neutrophil Cytoplasmic; Anti Neutrophil Cytoplasmic Antibody; Anti Neutrophil Cytoplasmic Antibodies; Antineutrophil Cytoplasmic Antibody; Anti-Neutrophil Cytoplasmic Antibody; Anti-Neutrophil Cytoplasmic Antibodies; p-ANCA; c-ANCA; Antineutrophil Cytoplasmic Antibodies; ANCA
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