Definition: A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.
Other names p145c kit; p145 c kit; kit Proto Oncogene Protein; c-kit, p145; c-kit, Proto-Oncogene Proteins; c-kit, Proto-Oncogene Protein; c kit Receptor; c kit Protein; Proto-Oncogene Protein, kit; Proto Oncogene Proteins c kit; Proto Oncogene Protein kit; Proto Oncogene Protein c kit; p145c-kit; p145 c-kit; SCF Receptor; Proto-Oncogene Protein kit; Proto-Oncogene Protein c-kit; CD117 Antigen; p145(c-kit); kit Proto-Oncogene Protein