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Transcription Factor AP-1

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Definition: A multiprotein complex composed of the products of c-jun and c-fos proto-oncogenes. These proteins must dimerize in order to bind to the AP-1 recognition site, also known as the TPA-responsive element (TRE). AP-1 controls both basal and inducible transcription of several genes.  in genetic transcription; /biosyn /physiol permitted; DF: AP 1   
See Also Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun 		Other names Activator Protein-1; AP-1; Transcription Factor AP 1; Enhancer-Binding Protein, AP-1; Activator Protein 1; AP 1 Enhancer Binding Protein; AP-1 Enhancer Binding Protein; AP-1 Enhancer-Binding Protein
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
11-hydroxy-14-isopropyl-8,11,13-podocarpatrien-19-oic acid  0   *Diterpenes Transcription Factor AP-1/antagonists & inhibitors. J Nat Prod. 2011 Mar 25;74(3):374-7
11-hydroxy-14-isopropyl-8,11,13-podocarpatrien-19-al  0   *Diterpenes Transcription Factor AP-1/antagonists & inhibitors. J Nat Prod. 2011 Mar 25;74(3):374-7
11,10-oxymethylenecyclopent-14-isopropyl-8,11,13-podocarpatriene  0   *Diterpenes Transcription Factor AP-1/antagonists & inhibitors. J Nat Prod. 2011 Mar 25;74(3):374-7
NFAB complex  0   *Transcription Factor AP-1 *Proto-Oncogene Proteins c-ets. EMBO J 1995 Sep 18;14(18):4501-13

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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