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Interleukin-12

More information in Books or onNLM PubMed
Definition: A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa and 35 kDa subunits. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells and plays a role in the stimulation of INTERFERON-GAMMA production by T-LYMPHOCYTES and NATURAL KILLER CELLS.  DF: IL 12 or IL12   
Pharmacological Action Adjuvants, Immunologic; Angiogenesis Inhibitors
See Also Immunity, Cellular
Examples Interleukin-12 Subunit p35; Interleukin-12 Subunit p40 		Other names p70, Interleukin-12; Interleukin 12 p70; Interleukin-12 p70; Interleukin 12; IL-12 p70; IL 12; Cytotoxic Lymphocyte Maturation Factor; Natural Killer Cell Stimulatory Factor; IL-12; Edodekin Alfa; IL12
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
IL-12 p80, mouse  0   *Interleukin-12 Protein Subunits. Am J Respir Crit Care Med 2006 Aug 15;174(4):461-70
99mTc-HYNIC-interleukin-12  0   *Organotechnetium Compounds *Interleukin-12. Eur J Nucl Med Mol Imaging 2006 Apr;33(4):474-82
STA 5326  0   *Morpholines *Triazines Interleukin-12/antagonists & inhibitors. Drug News Perspect 2004 Nov;17(9):607-14
Flexi-12 protein, human  0   *Recombinant Fusion Proteins *Interleukin-12. Hum Gene Ther 1997 Jun 10;8(9):1125-35

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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