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Receptors, GABA

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Definition: Cell-surface proteins that bind GAMMA-AMINOBUTYRIC ACID with high affinity and trigger changes that influence the behavior of cells. GABA-A receptors control chloride channels formed by the receptor complex itself. They are blocked by bicuculline and usually have modulatory sites sensitive to benzodiazepines and barbiturates. GABA-B receptors act through G-proteins on several effector systems, are insensitive to bicuculline, and have a high affinity for L-baclofen.  GEN; prefer specifics; DF: RECEPT GABA   
See Also GABA Plasma Membrane Transport Proteins
Examples Receptors, GABA-A; Receptors, GABA-B 		Other names gamma-Aminobutyric Acid Receptors; Receptors, gamma-Aminobutyric Acid; GABA Receptors; gamma Aminobutyric Acid Receptors; gamma Aminobutyric Acid Receptor; Receptors, gamma Aminobutyric Acid; Receptor, gamma-Aminobutyric Acid; Receptor, GABA; gamma-Aminobutyric Acid Receptor; GABA Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
translocator 18-kDa protein, zebrafish  0   *Receptors, GABA *Zebrafish Proteins. FASEB J 2009 Dec;23(12):4181-92
rho1 GABA(C) receptor, human  0   *Receptors, GABA. J Biol Chem 1997 May 23;272(21):13750-7
EXP-1 protein, C elegans  0   *Receptors, GABA *Caenorhabditis elegans Proteins. J Mol Biol 2005 Sep 16;352(2):313-8
TSPO protein, human  0   *Receptors, GABA.
Gabrb2 protein, mouse  0   *Receptors, GABA. J Pharmacol Exp Ther 2003 Jan;304(1):30-6
Bzrp protein, mouse  0   *Receptors, GABA. Neurochem Int 2002 Aug-Sep;41(2-3):109-14
6,6-dimethyl-3-(2-hydroxyethyl)thio-1-(thiazol-2-yl)-6,7-dihydro-2-benzothiophen-4(5H)-one  0   *Thiazoles *Thiophenes Receptors, GABA/agonists. J Med Chem 2002 Mar 14;45(6):1176-9
KN 244  0   *Bicyclo Compounds *Nitriles Receptors, GABA/antagonists & inhibitors. Br J Pharmacol 1999 Jul;127(6):1305-7
ethyl 6-benzyloxy-beta-carboline-3-carboyxlate  0   *Carbolines Receptors, GABA/agonists. Br J Pharamcol 1999 Jul;127(5):1231-9
GABA-C receptor  0   *Receptors, GABA. J Neurosci 1994 May;14(5 Pt 1):2648-58

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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