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Fusion Proteins, bcr-abl

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Definition: Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC.     
See Also Philadelphia Chromosome 		Other names bcr-abl Fusion Proteins; Oncogene Protein p210(bcr-abl); Oncogene Protein p190(bcr-abl); bcr abl Fusion Proteins; Fusion Proteins, bcr abl; p230(bcr-abl) Fusion Proteins; p210(bcr-abl) Fusion Proteins; p190(bcr-abl) Fusion Proteins; p185(bcr-abl) Fusion Proteins; Oncogene Protein p230(bcr-abl); Oncogene Protein p185(bcr-abl)
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Bcr-Abl tyrosine kinase  EC 2.7.1.-   *Protein-Tyrosine Kinases *Fusion Proteins, bcr-abl. Lancet 2001 Dec;358 Suppl:S11
abl-bcr fusion protein, human  0   *Fusion Proteins, bcr-abl. Leukemia 2000 Mar;14(3):419-26

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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