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Trichosanthin

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Definition: Plant-derived ribosome-inactivating protein (RIP) purified from the Chinese medicinal herb tian-hua-fen which is obtained from the root tubers of Trichosanthes kirilowii. It has been used as an abortifacient and in the treatment of trophoblastic tumors. GLQ223 (Compound Q), a highly purified form of trichosanthin, has been proposed as antiviral treatment for AIDS.  /drug eff /ultrastruct permitted   
Pharmacological Action Abortifacient Agents, Nonsteroidal; Anti-HIV Agents; Antineoplastic Agents, Phytogenic 		Other names alpha-Trichosanthin; Compound Q; GLQ-223; alpha Trichosanthin; GLQ 223; Tian-hua-fen; T'ien-hua-fen; GLQ223
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
bromodextran-trichosanthin  0   *Trichosanthin. Biochem Int 1991 Dec;25(6):1051-9
beta-trichosanthin  109191-07-3 beta-Trichosanthin  *Trichosanthin. Int J Pept Protein Res 1987;29(3):289

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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