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Factor VIIIa

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Definition: Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation to factor Va.     
See Also Coagulants 		Other names VIIIa, Coagulation Factor; Thrombin-Activated Factor VIII; Factor VIIIa, Coagulation; Factor VIII, Thrombin Activated; Activated Factor VIII; Factor VIIIa Light Chain; Factor VIIIa Heavy Chain, 92 kDa Isoform; Factor VIIIa Heavy Chain, 200 kDa Isoform; Blood Coagulation Factor VIII, Activated; Factor VIII, Thrombin-Activated; Factor VIII, Activated; Coagulation Factor VIIIa
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
cancer procoagulant  EC 3.4.22.26   *Cysteine Endopeptidases *Neoplasm Proteins Blood Coagulation Factors Neoplasm Proteins Factor VIIIa Factor IXa. J Clin Invest 1981;67(6):1665; JNCI 62(4):772;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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