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Cystatins

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Definition: A homologous group of endogenous CYSTEINE PROTEINASE INHIBITORS. The cystatins inhibit most CYSTEINE ENDOPEPTIDASES such as PAPAIN, and other peptidases which have a sulfhydryl group at the active site.  general or unspecified; prefer specifics   
Pharmacological Action Cysteine Proteinase Inhibitors
Examples Cystatin A; Cystatin B; Cystatin C; Cystatin M; Fetuins; Salivary Cystatins 		Other names Cystatin Superfamily; Cystatins, Type III; Cystatins, Type II; Cystatins, Type I; Cystatins, Type 3; Cystatins, Type 2; Cystatins, Type 1; Cystatin Related Proteins; Type III Cystatins; Type II Cystatins; Type I Cystatins; Type 3 Cystatins; Type 2 Cystatins; Type 1 Cystatins; Cystatin-Related Proteins; Stefins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
cystatin F, mouse  0   *Cystatins. Genomics 2000 Jul 1;67(1):87-91
CYS6 protein, Arabidopsis  0   *Cystatins *Arabidopsis Proteins. Plant Cell Rep 2009 Nov;28(11):1623-32
Rcet1 protein, mouse  0   *Cystatins. DNA Seq 2008 Feb;19(1):13-9
sialostatin L, Ixodes scapularis  0   *Cystatins. J Biol Chem 2006 Sep 8;281(36):26298-307
Cymg1 protein, mouse  0   *Cystatins. Acta Biochim Biophys Sin (Shanghai) 2005 Jan;37(1):11-8
Cst8 protein, rat  0   *Cystatins.
CST8 protein, human  0   *Cystatins.
CST9L protein, human  0   *Cystatins.
P22k15 protein, rat  0   *Cystatins.
Cst10 protein, mouse  0   *Cystatins. J Biol Chem 2003 Nov 28;278(48):48259-66
cystatin SC protein, mouse  0   *Cystatins. Biol Reprod 2002 Dec;67(6):1872-80
CST9 protein, human  0   *Cystatins. Biochem Biophys Res Commun 2003 Jan 31;301(1):176-82
Cst12 protein, mouse  0   *Cystatins. Endocrinology 2003 Mar;144(3):909-15
Cst11 protein, mouse  0   *Cystatins. Endocrinology 2003 Mar;144(3):909-15
canecystatin protein, sugarcane  0   *Plant Proteins *Cystatins. Biochem Biophys Res Commun 2002 Sep 6;296(5):1194-9
cystatin 11, Macaca mulatta  0   *Cystatins *Seminal Plasma Proteins. Endocrinology 2002 Jul;143(7):2787-96
chagasin, Trypanosoma  0   *Protozoan Proteins Cystatins. FEBS Lett 2001 Aug 24;504(1-2):41-4
Hv-CPI protein, Hordeum vulgare  0   *Plant Proteins *Cystatins. Plant Mol Biol 2001 Mar;45(5):599-608
nbcys protein, Nippostrongylus brasiliensis  0   *Cystatins. J Med Invest 2001 Feb;48(1-2):81-7
scN protein, soybean  0   *Cystatins *Soybean Proteins. Plant J 1998 May;14(3):371-9
SMC protein, Helianthus annuus  0   *Plant Proteins *Cystatins. J Biochem (Tokyo). 2000 Aug;128(2):161-6
Cst13 protein, mouse  0   *Cystatins. Gene 2000 Mar 7;245(1):103-8
Scb protein, Helianthus annuus  0   *Plant Proteins *Cystatins. J Biochem (Tokyo) 1998 Nov;124(5):911-6
CST7 protein, human  0   *Tumor Markers, Biological *Cystatins. Cancer Res 1999 Jan 1;59(1):151-8
chelidocystatin  0   *Cystatins Plant Proteins. Phytochemistry 1998 Nov;49(6):1645-9
cystatin protein, Castanea sativa  0   *Plant Proteins *Cystatins. Plant Mol Biol 1998 Dec;38(6):1235-42
Cst9 protein, mouse  0   *Cystatins. Proc Natl Acad Sci U S A 1998 Nov 24;95(24):14208-13
stefin D protein, Sus scrofa  183869-09-2   *Cystatins. FEBS Lett 1996 Oct 21;395(2-3):113-8
cystatin, egg-white  0   *Cystatins.
Pharma Action Cysteine Proteinase Inhibitors
secreted phosphoprotein 24  0   *Phosphoproteins Cystatins. J Biol Chem 1995 Jan 6;270(1):431-6
L68Q cystatin C  0   *Cystatins. Proc Natl Acad Sci U S A 1994 Feb 15;91(4):1416-20
MC protein, Solanum tuberosum  0   *Plant Proteins *Cystatins. Plant Mol Biol 1993 Nov;23(4):801-12
Andpro protein, rat  0   *Cystatins. Endocrinology 1993 Mar;132(3):2496-2502
Cst8 protein, mouse  149291-61-2   *Cystatins. Mol Endocrinol 1992 Oct;6(10):1653-64
cystatin protein, Zea mays  148466-75-5   *Plant Proteins *Cystatins. Eur J Biochem 1992 Nov 1;209(3):933-7
CST5 protein, human  142539-78-4   *Cystatins. J Biol Chem 1991;266(30):20538
Csta protein, rat  0   *Cystatins. FEBS Lett 1991;287(1-2):178
WCPI-3 protein, Wisteria floribunda  0   *Plant Proteins *Cystatins. J Biochem (Tokyo) 1990;108(4):604
cystatin C, N-terminal octapeptide  132512-75-5   *Peptide Fragments *Cystatins. Exp Cell Res 1990;188(1):16
cystatin C, N-terminal tetrapeptide  103745-46-6   *Peptide Fragments *Cystatins. Exp Cell Res 1990;188(1):16
cystatin B, des(Met(2)(1,2))  0   *Recombinant Fusion Proteins *Cystatins. Biol Chem Hoppe Seyler 1988;369(10):1167
thiolstatin  37353-41-6 Proteinase, cysteine, (S)  *Cystatins. J Reprod Fertil 1984;72(2):515

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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