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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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Definition
: A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.
Pharmacological Action
Dopamine Agents
;
Neurotoxins
Other names
MPTP; N-
Methyl-
4-
phenyl-
1,2,3,6-
tetrahydropyridine
Substance
CAS Registry & name
Categories
Source
Drugs
*
1-
amino-
4-
phenyl-
1,2,3,6-
tetrahydropyridine
0
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
J Neural Transm 1998;105(10-12):1253-64
1-
methyl-
4-
(4-
dimethylaminophenylethenyl)-
1,2,3,6-
tetrahydropyridine
0
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
Toxicol Appl Pharmacol 1996 Apr;137(2):163-72
4-
benzyl-
1-
cyclopropyl-
1,2,3,6-
tetrahydropyridine
158271-18-2
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
Biochemistry 1996 Mar 12;35(10):3335-40
1,2,3,6-
tetrahydro-
4-
(p-
hydroxyphenyl)-
1-
((3-
(p-
hydroxyphenyl)-
3-
cyclohexen-
1-
yl)methyl)pyridine
0
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
J Med Chem 1995 Dec 22;38(26):5007-14
1,2,3,6-
tetrahydro-
4-
(4-
hydroxyphenyl)-
1-
((3-
phenyl-
3-
cyclohexen-
1-
yl)methyl)pyridine
0
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
J Med Chem 1995 Dec 22;38(26):5007-14
PD 147693
0
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
J Chromatogr B Biomed Appl 1995 Mar 10;665(1):193-9
1,2,3,6-
tetrahydro-
4-
phenyl-
1-
((3-
phenyl-
3-
cyclohexen-
1-
yl)methyl)pyridine
150013-70-0
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
J Med Chem 1994 Oct 14;37(21):3523-33
4-
(4-
methoxy-
1,2,5-
thiadiazol-
3-
yl)-
1-
methyl-
1,2,3,6-
tetrahydropyridine
152720-15-5
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
Neurochem Int 1993 Nov;23(5):467-70
1-
methyl-
4-
(2-
(fluoromethyl)phenyl)-
1,2,3,6-
tetrahydropyridine
0
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives
Fluorine Radioisotopes
Neurotoxins.
J Med Chem 1993 Apr 30;36(9):1284-90
1-
methyl-
4-
(2'-
aminophenyl)-
1,2,3,6-
tetrahydropyridine
108114-93-8
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
J Neurochem 1993 Mar;60(3):1167-70
4-
cyclopropyl-
1-
methyl-
1,2,3,6-
tetrahydropyridine
142798-26-3
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
Chem Res Toxicol 1992 Sep-Oct;5(5):625-33
1-
cyclopropyl-
4-
phenyl-
1,2,3,6-
tetrahydropyridine
142798-22-9
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
Chem Res Toxicol 1992 Sep-Oct;5(5):625-33
1-
methyl-
4-
phenyl-
1,2,3,6-
tetrahydro-
3-
pyridinol
1891-24-3
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
Life Sci 1992;50(8):573-82
1-
methyl-
3-
phenyl-
1,2,3,6-
tetrahydropyridine
119375-00-7
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
Pharmacol Toxicol 1991;69(1):38
4-
benzyl-
1-
methyl-
1,2,3,6-
tetrahydropyridine
125927-26-6
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
Chem Res Toxicol 1990;3(2):133
4'-
amino-
1-
methyl-
4-
phenyl-
1,2,3,6-
tetrahydropyridine
106362-30-5
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
Life Sci 1990;47(21):1895
1-
methyl-
4-
phenyl-
1,2,3,6-
(tetrahydropyridine)-
N-
oxide
95969-40-7
*Cyclic N-Oxides
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
Life Sci 1990;47(9):815
1-
methyl-
4-
(2'-
ethylphenyl)-
1,2,3,6-
tetrahydropyridine
107316-68-7
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
J Neurochem 1990;55(3):870
1,3,3-
trimethyl-
4-
phenyl-
1,2,3,6-
tetrahydropyridine
99156-44-2
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
J Biol Chem 1989;264(36):21516
1-
ethyl-
4-
phenyl-
1,2,3,6-
tetrahydropyridine
13314-63-1
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
Res Commun Chem Pathol Pharmacol 1988;59(1):129
3'-
trifluoro-
N-
methyl-
4-
phenyl-
1,2,3,6-
tetrahydropyridine
17421-02-2
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
J Neurochem 1988;50(4):1319
2'-
fluoro-
N-
methyl-
4-
phenyl-
1,2,3,6-
tetrahydropyridine
75663-56-8
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
J Neurochem 1988;50(4):1319
1-
methyl-
4-
cyclohexyl-
1,2,3,6-
tetrahydropyridine
106351-84-2
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives
Neurotoxins.
Neurosci Lett 1987;79(1-2):151
1-
methyl-
4-
(3-
hydroxyphenyl)-
1,2,3,6-
tetrahydropyridine
105223-62-9
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
Res Commun Chem Pathol Pharmacol 1986;53(2):167
1-
ethyl-
4-
(3-
methoxyphenyl)-
1,2,3,6-
tetrahydropyridine
102538-16-9
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
J Med Chem 1986;29(8):1517
1-
methyl-
4-
(3-
methoxyphenyl)-
1,2,3,6-
tetrahydropyridine
73224-22-3
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
J Med Chem 1986;29(8):1517
1-
methyl-
4-
(2'-
methylphenyl)-
1,2,3,6-
tetrahydropyridine
102417-86-7
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
Pharma Action
Dopamine Antagonists
Eur J Pharmacol 1986;122(2):283
1-
methyl-
4-
(4-
chlorophenyl)-
1,2,3,6-
tetrahydropyridine
5048-08-8
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
Res Commun Chem Pathol Pharmacol 1985;50(1):57
N-
propyl-
4-
phenyl-
1,2,3,6-
tetrahydropyridine
90986-85-9 Pyridine, 1,2,3,6-
tetrahydro-
4-
phenyl-
1-
propyl-
, erythro
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
Life Sci 1984;34(26):2567
4-