Definition: Enzyme systems containing three different subunits and requiring ATP, S-adenosylmethionine, and magnesium for endonucleolytic activity to give random double-stranded fragments with terminal 5'-phosphates. They function also as DNA-dependent ATPases and modification methylases, catalyzing the reactions of EC 2.1.1.72 and EC 2.1.1.73 with similar site-specificity. The systems recognize specific short DNA sequences and cleave at sites remote from the recognition sequence. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.3.
DF: DNASE SS I
Other names DNase, Site-Specific, Type I; DNA Restriction Enzymes, Type I; Type I Restriction Enzymes; Restriction Endonucleases, Type I; Site Specific DNase, Type I; Deoxyribonucleases, Type I Site Specific; Type I Site-Specific Deoxyribonucleases; Type I Site-Specific DNase; Type I Site Specific Deoxyribonucleases; Type I Site Specific DNase; Site-Specific DNase, Type I; Deoxyribonucleases, Type I, Site-Specific; Deoxyribonucleases, Type I, Site Specific; DNase, Site Specific, Type I
