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Gemfibrozil

More information in Books or onNLM PubMed
Definition: A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol. These decreases occur primarily in the VLDL fraction and less frequently in the LDL fraction. Gemfibrozil increases HDL subfractions HDL2 and HDL3 as well as apolipoproteins A-I and A-II. Its mechanism of action has not been definitely established.     
Pharmacological Action Hypolipidemic Agents 		Other names Warner Lambert Brand of Gemfibrozil; PMS Gemfibrozil; NuGemfibrozil; Nu Pharm Brand of Gemfibrozil; Nu Gemfibrozil; Novo Gemfibrozil; GenGemfibrozil; Gen Gemfibrozil; Gemfibrozil, SBPA; Gemfibrozil, Healthsense; Gemfibrozil, GenRX; CI719; CI 719; Bayvit, Gemfibrozilo; ApoGemfibrozil; Apo Gemfibrozil; Warner-Lambert Brand of Gemfibrozil; United Drug Brand of Gemfibrozil; Trialmin; Terry White Chemists GemfibrozilDrugs* : LOPID; GEMFIBROZIL
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-(5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoyloxy)ethyl nicotinate  0   *Nicotinic Acids Gemfibrozil/*analogs & derivatives. Eur J Pharm Sci. 2011 Jan 14;43(3):99-108.
2-hydroxyethyl 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoate  0   Gemfibrozil/*analogs & derivatives. Eur J Pharm Sci. 2011 Jan 14;43(3):99-108.
3-((5-oxido-4-phenylsulfonyl-1,2,5-oxadiazol-3-yl)oxy)propyl 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoate  0   *Oxadiazoles Gemfibrozil/*analogs & derivatives. Nitric Oxide 2008 May;18(3):168-75
5-(2,5-dimethylphenoxy)-2-ethylpentanoic acid  0   Gemfibrozil/*analogs & derivatives. Bioorg Med Chem Lett 2002 Mar 11;12(5):817-21
5-(2,5-dimethylphenoxy)-2-methylpentanoic acid  0   Gemfibrozil/*analogs & derivatives. Bioorg Med Chem Lett 2002 Mar 11;12(5):817-21
gemfibrozil 1-O-acylglucuronide  91683-38-4   *Glucuronates Gemfibrozil/*analogs & derivatives. J Chromatogr B Biomed Appl 1995 Mar 24;665(2):345-53
CI 924  79520-77-7   Gemfibrozil/*analogs & derivatives. J Med Chem 1983;26(7):1020
penphenone  148-19-6   Gemfibrozil/*analogs & derivatives. Patol Fiziol Eksp Ter (4):50;1978; Vopr Med Khim 24(6):835;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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