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4-Hydroxyphenylpyruvate Dioxygenase

More information in Books or onNLM PubMed
Definition: An enzyme that catalyzes the conversion of 4-hydroxyphenylpyruvate plus oxygen to homogentisic acid and carbon dioxide. EC 1.13.11.27.  /defic: consider also TYROSINE /blood (IM) + AMINO ACID METABOLISM, INBORN ERRORS (IM)    Other names para-Hydroxyphenylpyruvate Oxidase; para-Hydroxyphenylpyruvate Hydroxylase; P-Hydroxyphenylpyruvate Oxidase; P-Hydroxyphenylpyruvate Hydroxylase; para Hydroxyphenylpyruvate Oxidase; para Hydroxyphenylpyruvate Hydroxylase; P Hydroxyphenylpyruvate Oxidase; P Hydroxyphenylpyruvate Hydroxylase; Oxidase, para-Hydroxyphenylpyruvate; Oxidase, P-Hydroxyphenylpyruvate; Hydroxylase, para-Hydroxyphenylpyruvate; Hydroxylase, P-Hydroxyphenylpyruvate; Dioxygenase, 4-Hydroxyphenylpyruvate
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
diketonitrile  0   *Nitriles *Sulfones 4-Hydroxyphenylpyruvate Dioxygenase/antagonists & inhibitors. Drug News Perspect 2003 Oct;16(8):493-6
3-fluoro-3-(4-nitrophenyl)pyruvic acid  0   *Phenylpyruvic Acids 4-Hydroxyphenylpyruvate Dioxygenase/antagonists & inhibitors. Bioorg Med Chem Lett 1999 Jul;7(7):1459-65
3-fluoro-3-phenylpyruvic acid  0   *Phenylpyruvic Acids 4-Hydroxyphenylpyruvate Dioxygenase/antagonists & inhibitors. /antagonists & inhibitors Bioorg Med Chem Lett 1999 Jul;7(7):1459-65
sulcotrione  99105-77-8   *Cyclohexanones *Mesylates 4-Hydroxyphenylpyruvate Dioxygenase/antagonists & inhibitors. FEBS Lett 1993 Mar 1;318(2):162-6
nitisinone  104206-65-7   *Cyclohexanones *Nitrobenzoates 4-Hydroxyphenylpyruvate Dioxygenase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Lancet 1992 Oct 3;340(8823):813-7ORFADIN

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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