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Trichothecenes

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Definition: Usually 12,13-epoxytrichothecenes, produced by Fusaria, Stachybotrys, Trichoderma and other fungi, and some higher plants. They may contaminate food or feed grains, induce emesis and hemorrhage in lungs and brain, and damage bone marrow due to protein and DNA synthesis inhibition.     
Pharmacological Action Poisons
Examples T-2 Toxin; Trichodermin 		Other names Trichothecene Epoxides; Epoxytrichothecenes; Epoxides, Trichothecene
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
roritoxin E  0   *Trichothecenes *Macrolides. Planta Med. 2010 Jul;76(10):1004-6
deoxynivalenol sulfonate  0   *Trichothecenes. Arch Anim Nutr 2008 Aug;62(4):263-86
deoxynivalenol-3-glucoside  0   *Glucosides *Trichothecenes. J Agric Food Chem 2009 Apr 22;57(8):3187-94
12'-hydroxyroridin E  0   *Trichothecenes. J Antibiot (Tokyo). 2006 Aug;59(8):451-5
2',3'-deoxyroritoxin D  0   *Trichothecenes. J Antibiot (Tokyo). 2006 Aug;59(8):451-5
roridin Q  0   *Trichothecenes. J Antibiot (Tokyo). 2006 Aug;59(8):451-5
roridin R  0   *Trichothecenes. J Antibiot (Tokyo). 2006 Aug;59(8):451-5
tenuipesine A  0   *Trichothecenes. Org Lett. 2004 Nov 25;6(24):4531-3
satratoxin H 12',13'-diacetate  0   *Trichothecenes. Planta Med 2002 Dec;68(12):1088-91
satratoxin H 13'-acetate  0   *Trichothecenes. Planta Med 2002 Dec;68(12):1088-91
verrucarin L acetate  0   *Trichothecenes. Planta Med 2002 Dec;68(12):1088-91
calcarisporin B1  0   *Trichothecenes. J Asian Nat Prod Res 2002 Sep;4(3):179-83
16-hydroxyroridin E  0   *Trichothecenes. J Nat Prod 2002 May;65(5):742-4
14'-hydroxymytoxin B  0   *Trichothecenes. J Nat Prod 2002 May;65(5):742-4
verrucarin M  0   *Trichothecenes. J Antibiot (Tokyo) 2001 Nov;54(11):980-3
roridin M  0   *Trichothecenes. J Antibiot (Tokyo) 2001 Nov;54(11):980-3
roridin L  0   *Trichothecenes. J Antibiot (Tokyo) 2001 Nov;54(11):980-3
4-acetyl-12,13-epoxy-9-trichothecene-3,15-diol  0   *Trichothecenes Apoptosis. Biol Pharm Bull 2001 Jul;24(7):785-9
8-acetoxyroridin E  0   *Trichothecenes. J Antibiot (Tokyo) 2001 Jun;54(6):517-20
8-acetoxyroridin H  0   *Trichothecenes. J Antibiot (Tokyo) 2001 Jun;54(6):517-20
4-acetoxyscirpene-3,15-diol  0   *Trichothecenes. Life Sci 2001 Jun 1;69(2):229-37
12,13-deoxyroridin E  0   *Trichothecenes Marine Toxins. J Nat Prod 2001 Mar;64(3):396-8
curvularol  0   *Trichothecenes. J Antibiot (Tokyo) 2001 Jan;54(1):10-6
roridin D  14682-29-2   Trichothecenes Mycotoxins. Arch Environ Contam Toxicol 1989 May-Jun;18(3):388-95
trichothecene 3-O-acetyltransferase  EC 2.3.1.-   *Acetyltransferases Fungal Proteins Trichothecenes. J Biol Chem 1998 Jan 16;273(3):1654-61
YM 47525  0   Trichothecenes. J Antibiot (Tokyo) 1997 Sep;50(9):778-80
YM 47524  0   Trichothecenes. J Antibiot (Tokyo) 1997 Sep;50(9):778-50
3,15-diacetyldeoxynivalenol  99604-10-1   *Trichothecenes. Appl Environ Microbiol 1996 Oct;62(10):3858-60
harzianum A  156250-74-7 Trichothec-9-en-4-ol, 12,13-epoxy-, hydrogen 2,4,6-octatrienedioate, (4beta(2Z,4E,6E))  *Trichothecenes. J Nat Prod 1994 Mar;57(3):422-5
4,15-diacetylnivalenol  14287-82-2   *Trichothecenes Mycotoxins. Appl Environ Microbiol 1993 May;59(5):1264-8
8-pentanoylneosolaniol  116163-74-7   *Trichothecenes Cytotoxins Fusarium. J Nat Prod 1991 Sep-Oct;54(5):1303-8
8-hexanoylneosolaniol  118143-01-4   *Trichothecenes Fusarium. J Nat Prod 1991 Sep-Oct;54(5):1303-8
4-deacetylneosolaniol  74833-39-9   *Trichothecenes. Biochem Pharmacol 1991;42(4):949
nivalenol tetraacetate  14287-83-3   *Trichothecenes Mycotoxins. Appl Environ Microbiol 1991;57(4):1026
12,13-epoxytrichothec-9-ene  37133-74-7   *Trichothecenes. J Biol Chem 1990;265(12):6713
isotrichodermin  91423-90-4   *Trichothecenes. J Biol Chem 1990;265(12):6713
isoverrucarol  38818-67-6   *Trichothecenes Mycotoxins. Appl Environ Microbiol 1990;56(1):260
12,13-deoxytrichoverrin  123025-01-4   *Trichothecenes Plant Extracts. J Nat Prod 1989;52(3):663
baccharinoid B4  63783-94-8   *Trichothecenes. Zentralb Veterinarmed (A) 1989;36(2):152
roritoxin B  102852-49-3   *Trichothecenes. Zentralbl Veterinarmed (A) 1989;36(2):152
myrotoxin B  99486-49-4   *Trichothecenes. Zentralbl Veterinarmed (A) 1989;36(2):152
8-ketoverrucarin A  74516-63-5   *Trichothecenes Mycotoxins. Biomed Environ Mass Spectrom 1988;15(4):185
apotrichodiol  104148-45-0   *Trichothecenes Mycotoxins. J Biol Chem 1987;262(32):15354
sambucinol  90044-33-0   *Trichothecenes Mycotoxins. J Biol Chem 1987;262(32):15348
trichoverrol A  76739-71-4 Trichothec-9-ene-4,15-diol, 12,13-epoxy-, 4-(6,7-dihydroxy-2,4-octadienoate), (4beta(2Z,4E,6S,7S))  *Trichothecenes. Appl Environ Microbiol 1986;51(5):915
deepoxy-deoxynivalenol  88054-24-4   *Trichothecenes. J Assoc Off Anal Chem 1986;69(1):41
trichothecolone  2199-06-6   *Trichothecenes Mycotoxins. Appl Environ Microbiol 1986;51(1):217
15-acetyldeoxynivalenol  88337-96-6 Trichothec-9-en-8-one, 15-(acetyloxy)-12,13-epoxy-3,7-dihydroxy-, (3alpha,7alpha)  *Trichothecenes. Mycopathologia 1985;91(1):23
15-acetoxy-3-hydroxy-3,4-O,O-ethylidene-12,13-epoxytrichothec-9-ene  79320-89-1   *Trichothecenes. J Med Chem 1985;28(7):958
2'-methyl-15-acetoxy-3-hydroxy-12,13-epoxytrichotheceno(3,4-d)oxazole  79320-86-8   *Trichothecenes. J Med Chem 1985;28(7):958
3-ketoanguidin  2269-44-5   *Trichothecenes. J Med Chem 1985;28(7):958
monoacetoxyscirpenol  96699-75-1   *Trichothecenes Mycotoxins. Tierarztl Prax 1985;Suppl 1:8
3-acetyldeoxynivalenol  50722-38-8   *Trichothecenes. Toxicol Lett 1984;23(2):215
PD 113325  90297-50-0 Verrucarin A, 2',3'-didehydro-2'-deoxy-13'-hydroxy-, (2'E)  Trichothecenes. J Antibiot (Tokyo) 1984;37(8):823
4-deoxyverrucarol  91987-94-9   *Trichothecenes. J Nat Prod 1984;47(3):514
roridin H  29953-50-2   Trichothecenes. J Med Chem 1984;27(2):239
acetyldeoxynivalenol  54648-10-1   *Trichothecenes Mycotoxins. Appl Environ Microbiol 1983;46(3):625
roridin A  14729-29-4   *Trichothecenes Mycotoxins. Mycopathologia 1983;81(3):187
nivalenol  23282-20-4   *Trichothecenes Mycotoxins. Arch Geschwulstforsch 1983;53(1):9
16-hydroxytrichodermadienediol B  86023-75-8 Trichothec-9-ene-4,16-diol, 12,13-epoxy-, 4-(6,7-dihydroxy-2,4-octadienoate), (4beta(2Z,4E,6S,7R))  Trichothecenes. J Antibiot (Tokyo) 1983;36(4):459
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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