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Thiouracil

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Definition: Occurs in seeds of Brassica and Crucifera species. Thiouracil has been used as antithyroid, coronary vasodilator, and in congestive heart failure although its use has been largely supplanted by other drugs. It is known to cause blood dyscrasias and suspected of terato- and carcinogenesis.  a thyroid antag   
Pharmacological Action Antithyroid Agents; Vasodilator Agents
Examples Methylthiouracil; Propylthiouracil
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Metaltite  0   *Methacrylates Thiouracil/*analogs & derivatives Dental Cements. Dent Mater J 2005 Dec;24(4):654-60
5-dimethylaminomethyl-2-thiouracil  0   Thiouracil/*analogs & derivatives. J Inorg Biochem 2002 May 21;90(1-2):22-37
5-(2-thiazolylazo)thiouracil  0   Thiouracil/*analogs & derivatives. Spectrochim Acta A Mol Biomol Spectrosc 2001 Mar 1;57(3):411-7
5-bromo-2-thiouracil  0   Thiouracil/*analogs & derivatives Bromine Radioisotopes. Nucl Med Biol 2000 Nov;27(8):845-9
5-phenylthioacyclouridine  0   Thiouracil/*analogs & derivatives. Biochem Pharmacol. 2000 Sep 15;60(6):851-6
4-thiouracil  591-28-6   Thiouracil/*analogs & derivatives. Nature 1998 Sep 17;395(6699):260-3
5-ethyl-6-(1-naphthylmethyl)-2-thiouracil  0   Thiouracil/*analogs & derivatives. Acta Chem Scand 1997 Mar;51(3 Suppl):426-30
6-anilino-2-thiouracil  98421-02-4   *Aniline Compounds Thiouracil/*analogs & derivatives. Eur J Endocrinol 1996 Apr;134(4):519-23
5-isopropyl-1-((hydroxyethoxy)methyl)-6-(3,5-dimethylphenythio)-2-thiouracil  137897-89-3   Thiouracil/*analogs & derivatives HIV Reverse Transcriptase/antagonists & inhibitors. J Biol Chem 1992 Jun 15;267(17):11831-8
6-phenylthiouracil  36822-11-4   Thiouracil/*analogs & derivatives. J Chromatogr 1989;489(1):127
5-dihydroxyboryl-2-thiouracil  125177-38-0   *Boron Compounds Thiouracil/*analogs & derivatives. Basic Life Sci 1989;50:233
2,4-dithiouracil  2001-93-6   Thiouracil/*analogs & derivatives. Ann Univ Mariae Curie Skiodowska [Med] 1983;38:135
iodothiouracil  5984-97-4   Thiouracil/*analogs & derivatives. Cancer Res 1983;43(3):1316
1,3-dimethyl-4-thiouracil  49785-67-3 2(1H)-pyrimidinone, 3,4-dihydro-1,3-dimethyl-4-thioxo  Thiouracil/*analogs & derivatives. Photochem Photobiol 1980;32(5):683
benzylthiouracil  6336-50-1   Thiouracil/*analogs & derivatives Uridine Phosphorylase/antagonists & inhibitors. C R Soc Biol (Paris) 172(4):691;1978
2-thio-4-hydrazinouracil  32084-28-9   Thiouracil/*analogs & derivatives. Neoplasma 22(3):255;1975
4,5-diamino-2-thiouracil  1004-76-8 4,5-diamino-6-hydroxy-2-thiopyrimidine  Thiouracil/*analogs & derivatives. J Pharm Sci 63(4):622;1974
1-benzyl-2-thio-5,6-dihydrouracil  19341-60-7   Thiouracil/*analogs & derivatives.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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