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Tetrodotoxin

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Definition: An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.  /antag permitted but consider also ANTITOXINS   
Pharmacological Action Anesthetics, Local; Poisons; Sodium Channel Blockers 		Other names Tarichatoxin; Fugu Toxin; Toxin, Fugu; Tetradotoxin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
6,11-dideoxytetrodotoxin  0   Tetrodotoxin/*analogs & derivatives. Toxicon 2007 Dec 1;50(7):947-51
5,6,11-trideoxytetrodotoxin  0   Tetrodotoxin/*analogs & derivatives. Org Lett 2006 Oct 12;8(21):4971-4
4-S-cysteinyltetrodotoxin  0   Cysteine/*analogs & derivatives Tetrodotoxin/*analogs & derivatives. Chem Res Toxicol 2005 May;18(5):865-71
8,11-dideoxytetrodotoxin  0   Tetrodotoxin/*analogs & derivatives. Org Lett 2002 Aug 8;4(16):2679-82
5-deoxytetrodotoxin  0   *Tetrodotoxin. Biosci Biotechnol Biochem 1999 May;63(5):961-3
11-oxotetrodotoxin  123665-88-3   Tetrodotoxin/*analogs & derivatives. Toxicon 1996 Apr;34(4):407-16
6-epitetrodotoxin  112318-40-8 Tetrodotoxin, (6beta)  *Tetrodotoxin Isomerism. Toxicon 1992 May-Jun;30(5-6):635-43
11-deoxytetrodotoxin  113564-23-1   *Tetrodotoxin. Toxicon 1990;28(2):238
anhydrotetrodotoxin  13072-89-4 Tetrodotoxin, 4,9-dideoxy-4,9-epoxy-, (4beta,9beta)  Tetrodotoxin/*analogs & derivatives Sodium Channels. Toxicon 1985;23(5):725
4-epitetrodotoxin  98242-82-1 Tetrodotoxin, (4beta)  Tetrodotoxin/*analogs & derivatives Sodium Channels/drug effects. Toxicon 1985;23(5):725
N,N'-ethylenediamineditetrodotoxin  91260-89-8 Tetrodotoxin, 11,11'-(1,2-ethanediyldiimino)bis(11-deoxy-, (E))  Tetrodotoxin/*analogs & derivatives. Anal Biochem 1984;139(1):149
11-nortetrodotoxin  70170-72-8 Tetrodotoxin, 6-de(hydroxymethyl)-6-deoxy-6-oxo  Tetrodotoxin/*analogs & derivatives. Anal Biochem 1982;126(1):153
chiriquitoxin  61132-15-8   *Tetrodotoxin Amphibian Venoms. J Physiol 272(1):54;1977; J Physiol 284:88;1978
tetrodamine  41963-49-9   Tetrodotoxin/*analogs & derivatives. J Am Chem Soc 94(26):9217;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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