encyclopedia of medical concepts
ψ
ψ
Streptonigrin
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Definition
: Complex cytotoxic antibiotic obtained from Streptomyces flocculus or S. rufochronmogenus. It is used in advanced carcinoma and causes leukopenia.
Pharmacological Action
Antibiotics, Antineoplastic
Other names
Rufocromomycin; Bruneomycin; NSC45383; NSC 45383; Nigrin; NSC-
45383; Brunemycin
Substance
CAS Registry & name
Categories
Source
Drugs
*
decarboxy-
2'-
(hydroxymethyl)-
demethyllavendamycin
0
Streptonigrin/*analogs & derivatives.
J Med Chem 2005 Dec 1;48(24):7733-49
7-
(1-
methyl-
2-
oxopropyl)streptonigrin
0
Streptonigrin/*analogs & derivatives.
J Nat Prod 2002 May;65(5):721-4
retrostatin
0
*Streptonigrin.
J Antibiot (Tokyo) 1983 Jul;36(7):761-9
2'-
decarboxy-
2'-
aminostreptonigrin
143139-76-8
Streptonigrin/*analogs & derivatives.
J Antibiot (Tokyo) 1992 Jun;45(6):1002-4
10'-
desmethoxystreptonigrin
136803-89-9
Streptonigrin/*analogs & derivatives.
J Antibiot (Tokyo) 1992 Apr;45(4):454-7
di-
2',8'-
O-
di-
5',5'-
N,N-
methylstreptonigrone
140458-71-5
Streptonigrin/*analogs & derivatives
Streptomyces.
J Antibiot (Tokyo) 1992 Feb;45(2):227-34
tri-
1',5',5'-
N,N,N-
mono-
8'-
O-
methylstreptonigrone
140458-70-4
Streptonigrin/*analogs & derivatives
Streptomyces.
J Antibiot (Tokyo) 1992 Feb;45(2):227-34
10'-
O-
demethylstreptonigrin
105933-56-0
Streptonigrin/*analogs & derivatives.
J Antibiot (Tokyo) 1986;39(7):1013
streptonigrone
96684-38-7
Streptonigrin/*analogs & derivatives.
J Antibiot 1985;38(4):516
lavendamycin
81645-09-2 9H-
Pyrido(3,4-
b)indole-
3-
carboxylic acid, 1-
(7-
amino-
5,8-
dihydro-
5,8-
dioxo-
2-
quinolinyl)-
4-
methyl
Streptonigrin/*analogs & derivatives.
J Antibiot (Tokyo) 1982;35(3):259