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Steroid 12-alpha-Hydroxylase

More information in Books or onNLM PubMed
Definition: A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol.      Other names Sterol 12-alpha-Hydroxylase; Steroid 12-Monooxygenase; 12-alpha-Hydroxylase; 12alpha Hydroxylase; 12 alpha-Hydroxylase, Sterol; 12 alpha Hydroxylase; Sterol 12 alpha-Hydroxylase; Steroid-12-Monooxygenase; Steroid-12-Hydroxylase; Steroid 12-Hydroxylase; Cytochrome P450 CYP8B1; Cytochrome P450 8B1; CYP8B1; 12alpha-Hydroxylase; alpha-Hydroxylase, Sterol 12; Sterol 12 alpha Hydroxylase; Steroid 12 alpha Hydroxylase; Steroid 12 Monooxygenase; Steroid 12 Hydroxylase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
7-hydroxycholesterol-12-alpha-hydroxylase  EC 1.14.99.-   *Steroid 12-alpha-Hydroxylase. Biochem Biophys Res Commun 1983;113(1):212
7 alpha-hydroxy-4-cholesten-3-one-12 alpha monooxygenase  EC 1.14.99.-   *Steroid 12-alpha-Hydroxylase. J Biol Chem 1982;257(14):8030
chenodeoxycholate hydroxylase  EC 1.14.-   *Steroid 12-alpha-Hydroxylase. Ann NY Acad Sci 1980;349;399

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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