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Quinone Reductases

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Definition: NAD(P)H:(quinone acceptor) oxidoreductases. A family that includes three enzymes which are distinguished by their sensitivity to various inhibitors. EC 1.6.99.2 (NAD(P)H DEHYDROGENASE (QUINONE);) is a flavoprotein which reduces various quinones in the presence of NADH or NADPH and is inhibited by dicoumarol. EC 1.6.99.5 (NADH dehydrogenase (quinone)) requires NADH, is inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivatives. EC 1.6.99.6 (NADPH dehydrogenase (quinone)) requires NADPH and is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol.     
Examples NAD(P)H Dehydrogenase (Quinone) 		Other names Reductases, Quinone; Reductases, Menaquinone; Menaquinone Reductases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Zta1 protein, S cerevisiae  EC 1.6.5.5   *Quinone Reductases *Saccharomyces cerevisiae Proteins. J Struct Biol. 2011 Oct;176(1):112-8.
6-methoxy-9-methyl-(1,3)dioxolo(4,5-h)quinolin-8(9H)-one  0   *Quinolones *Benzodioxoles Aromatase Quinone Reductases/antagonists & inhibitors. J Med Chem 2009 Apr 9;52(7):1873-84
NuoF protein, E coli  EC 1.6.99.5   *Quinone Reductases *Escherichia coli Proteins. FEBS Lett 2005 Jun 6;579(14):3164-8
YhdH protein, E coli  EC 1.6.99.-   *Quinone Reductases *Escherichia coli Proteins. Acta Crystallogr D Biol Crystallogr 2004 Oct;60(Pt 10):1855-62
FQR1 protein, Arabidopsis  EC 1.6.99.-   *Quinone Reductases *Arabidopsis Proteins. Plant Physiol 2002 Feb;128(2):578-90
NRH - quinone oxidoreductase2  EC 1.6.99.-   *Quinone Reductases. Chem Biol Interact 2000 Dec 1;129(1-2):99-112
hydroxyhydroquinone reductase  EC 1.6.99.-   *Quinone Reductases. Arch Microbiol 2000 Mar;173(3):206-12
1,4-benzoquinone reductase  EC 1.6.99.-   *Quinone Reductases. Arch Biochem Biophys 1996 Jul 1;331(1):31-40
coenzyme F420H2 - 2,3-dimethyl-1,4-naphthoquinone oxidoreductase  EC 1.6.5.-   *Quinone Reductases. Eur J Biochem 1994 Jul 15;223(2):503-11
NADPH - phenanthrenequinone oxidoreductase  EC 1.6.99.-   *Quinone Reductases. Toxicol Appl Pharmacol 1994 Apr 125(2):184-91
sodium-translocating NADH-quinone reductase  EC 1.6.5.-   *Bacterial Proteins *Quinone Reductases. J Bioenerg Biomembr 1993 Aug;25(4):385-91
sulfide quinone reductase  EC 1.8.5.-   *Quinone Reductases. FEBS Lett 1992 Mar 9;299(2):127-30
dinitropyrene nitroreductase  EC 1.6.99.-   *Nitroreductases *Quinone Reductases. Carcinogenesis 1991;12(4):697
isochromanequinone reductase  EC 1.6.99.-   *Quinone Reductases. Antimicrob Agents Chemother 1986;29(1):13
NADH dehydrogenase (quinone)  EC 1.6.99.5   *Quinone Reductases Iron-Sulfur Proteins. J Biol Chem 1984;259(12):7785
photooxidase, Rhodospirillum rubrum  EC 1.6.99.-   *Bacterial Proteins *Quinone Reductases. Eur J Biochem 1982;121(2):343
dichlorophenolindophenol reductase  EC 1.6.99.-   *Quinone Reductases. Biochemistry 1981;20(26):7483
NADH duroquinone reductase  EC 1.6.99.-   *Quinone Reductases. Endocrinology 1981;109(2):664
ubiquinol-1 oxidase  EC 1.6.99.-   *Quinone Reductases. Arch Biochem Biophys 1981;208(1):11
benzo(a)pyrene-3,6-quinone reductase  EC 1.6.99.-   *Quinone Reductases. Biochem Biophys Res Commun 83(4):1291;1978

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