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Pteroylpolyglutamic Acids

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Definition: Derivatives of folic acid (pteroylglutamic acid). In gamma-glutamyl linkage they are found in many tissues. They are converted to folic acid by the action of pteroylpolyglutamate hydrolase or synthesized from folic acid by the action of folate polyglutamate synthetase. Synthetic pteroylpolyglutamic acids, which are in alpha-glutamyl linkage, are active in bacterial growth assays.  deficiency: coordinate PTEROYLPOLYGLUTAMIC ACIDS /defic (IM) with FOLIC ACID DEFICIENCY (IM)   
Pharmacological Action Vitamin B Complex 		Other names Polyglutamate Folates; Folate Polyglutamates; Polyglutamates, Folate; Folates, Polyglutamate; Acids, Pteroylpolyglutamic; Pteroylpolyglutamates
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
5-methyltetrahydrofolate pentaglutamate  0   *Pteroylpolyglutamic Acids *Tetrahydrofolates. J Biol Chem 1999 Dec 31;274(53):37559-64
N-(N-(4-deoxy-4-amino-10-methylpteroyl)-4-fluoroglutamyl)-gamma-glutamate  124716-15-0   *Pteroylpolyglutamic Acids. J Med Chem 1990;33(3):1022
7-hydro-8-methylpteroylglutamylglutamic acid  108402-49-9   *Pteroylpolyglutamic Acids. J Antibiot (Tokyo) 1987;40(3):251
5-methyltetrahydropteroylpentaglutamate  39555-46-9 L-Glutamic acid, N-(N-(N-(N-(N-(4-(((2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-gamma-glutamyl)-L-gamma-glutamyl)-L-gamma-glutamyl)-L-gamma-glutamyl)  *Pteroylpolyglutamic Acids. Biochem Biophys Res Commun 1985;127(3):746
triglutamate folate  29701-38-0   *Pteroylpolyglutamic Acids. J Biol Chem 1984;259(18):11346
hexaglutamate folate  35409-55-3   *Pteroylpolyglutamic Acids. Drug Nutri Interact 1983;2(1):57
pteropterin  89-38-3   *Pteroylpolyglutamic Acids. Vitam Horm 1983;40:45
pteroylpentaglutamic acid  33611-85-7   *Pteroylpolyglutamic Acids. Biochim Biophys Acta 1982;692(1):161
tetrahydropteroylpentaglutamate  41520-73-4 L-Glutamic acid, N-(N-(N-(N-(N-(4-(((2-amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-gamma-glutamyl)-L-gamma-glutamyl)-L-gamma-glutamyl)-L-gamma-glutamyl)  *Pteroylpolyglutamic Acids. Nutr Rev 1981;39(11):408
dihydropteroyl hexaglutamate  49637-65-2 L-Glutamic acid, N-(N-(N-(N-(N-(N-(4-(((2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-gamma-glutamyl)-L-gamma-glutamyl)-L-gamma-glutamyl)-L-gamma-glutamyl)-L-gamma-glutamyl)  *Pteroylpolyglutamic Acids. Biosystems 1980;12(3-4):240
methylenetetrahydropteroylpolyglutamate  0   *Pteroylpolyglutamic Acids. Biochemistry 1980;19(10):2040
dihydropteroylpolyglutamate  0   *Pteroylpolyglutamic Acids. Biochemistry 1980;19(10):2040
10-formylpteroylpentaglutamate  41432-72-8 L-Glutamic acid, N-(N-(N-(N-(N-(4-(((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)formylamino)benzoyl)-L-gamma-glutamyl)-L-gamma-glutamyl)-L-gamma-glutamyl)-L-gamma-glutamyl)  *Pteroylpolyglutamic Acids. Biochem J 1980;186(1):235
pteroylglutamyl-gamma-hexaglutamate  6484-74-8   *Pteroylpolyglutamic Acids. J Clin Invest 59:933;1977

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