Protein Processing (definition)

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Protein Processing, Post-Translational

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Definition: Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.

coord IM with specific protein /metab (IM) and with specific modification, for example, ACYLATION; AMINATION; DEAMINATION; PROTEIN ISOPRENYLATION; etc.; do not confuse with PROTEIN MODIFICATION, TRANSLATIONAL; DF: PROTEIN PROC POST
See Also Histone Code
Examples Protein Prenylation; Protein Splicing; Ubiquitination; Unfolded Protein Response

Other names Protein Modification, Post-Translational; Post-Translational Protein Modification; Amino Acid Modification, Post-Translational; Protein Modifications, Post-Translational; Protein Modification, Post Translational; Processing, Posttranslational Protein; Processing, Post-Translational Protein; Posttranslational Modification; Post-Translational Protein Modifications; Post-Translational Modification; Post Translational Protein Processing; Post Translational Protein Modification; Post Translational Modifications; Post Translational Amino Acid Modification; Modifications, Posttranslational; Modifications, Post-Translational Protein; Modifications, Post-Translational; Modification, Posttranslational; Modification, Post-Translational Protein; Modification, Post-Translational

Substance	CAS Registry & name	Categories	Source
RCE1 protein, human	EC 3.4.22	*Endopeptidases Lipoproteins Protein Processing, Post-Translational.
Rce1 protein, mouse	EC 3.4.22	*Endopeptidases Protein Processing, Post-Translational.
chloroplast processing enzyme protein, Arabidopsis	EC 3.4.24.-	Metalloendopeptidases Arabidopsis Proteins Protein Processing, Post-Translational.
actin N-acetylaminopeptidase	EC 3.4.11.-	*Aminopeptidases Protein Processing, Post-Translational.	J Biol Chem 1992 Feb 5;267(4):2671-8
stromal processing peptidase	EC 3.4.24.-	Metalloendopeptidases Plant Proteins Protein Processing, Post-Translational.	J Biol Chem 1991;266(35):23606
glycylpeptide N-tetradecanoyltransferase	EC 2.3.1.97	*Acyltransferases Protein Processing, Post-Translational.	J Biol Chem 1987;262(3):1030
protein-tyrosine sulfotransferase	EC 2.8.2.20	*Sulfotransferases Protein Processing, Post-Translational.	J Biol Chem 1983;258(18):11326
leucyltransferase	EC 2.3.2.6	*Aminoacyltransferases Protein Processing, Post-Translational.	J Bacteriol 135(3):1154;1978; J Biol Chem 254(5):1724;1979; Molec Cell Biol 2(1):3;1973
arginyltransferase	EC 2.3.2.8	*Aminoacyltransferases Protein Processing, Post-Translational.	Biochem Biophys Res Commun 64(3):926;1975; Biochim Biophys Acta 477:394;1977; Mech Ageing Dev 1980;12(2):197

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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