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Protein Disulfide Reductase (Glutathione)

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Definition: An enzyme that catalyzes the reduction of a protein-disulfide in the presence of glutathione, forming a protein-dithiol. Insulin is one of its substrates. EC 1.8.4.2.      Other names Glutathione Protein Disulfide Oxidoreductase; Glutathione Insulin Transhydrogenase; Transhydrogenase, Glutathione Insulin; Thiol Protein Disulfide Oxidoreductase; Thiol Disulfide Oxidoreductase; Oxidoreductase, Thiol-Protein Disulfide; Oxidoreductase, Thiol-Disulfide; Insulin Transhydrogenase, Glutathione; Disulfide Oxidoreductase, Thiol-Protein; Thiol-Protein Disulfide Oxidoreductase; Thiol-Disulfide Oxidoreductase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
TMX4 protein, human  EC 1.8.4.2   *Membrane Glycoproteins *Protein Disulfide Reductase (Glutathione). Biochem J 2010 Jan 1;425(1):195-205
Ccmg protein, E coli  EC 1.8.4.2   *Protein Disulfide Reductase (Glutathione) *Escherichia coli Proteins. Acta Crystallogr D Biol Crystallogr 2003 Sep;59(Pt 9):1674-5
TXNDC12 protein, human  EC 1.8.4.2   *Protein Disulfide Reductase (Glutathione). J Biol Chem 2003 Aug 1;278(31):28912-20
BdbD protein, Bacillus subtilis  EC 1.8.4.2   *Bacterial Proteins *Protein Disulfide Reductase (Glutathione). J Bacteriol 2002 Mar;184(5):1423-9
BdbC protein, Bacillus subtilis  EC 1.8.4.2   *Bacterial Proteins *Protein Disulfide Reductase (Glutathione). J Bacteriol 2002 Mar;184(5):1423-9

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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