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Pregnanediones

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Definition: Pregnane derivatives in which two side-chain methyl groups or two methylene groups in the ring skeleton (or a combination thereof) have been oxidized to keto groups.     
Examples Alfaxalone Alfadolone Mixture; 5-alpha-Dihydroprogesterone; Tetrahydrocortisone 		Other names Dioxopregnanes; Diketopregnanes
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3beta,16alpha,17alpha-trihydroxy-5alpha-pregnane-7,20-dione  0   Pregnanediones. J Steroid Biochem Mol Biol. 2010 Aug;121(3-5):574-81
12-acetoxy-11-((3,4-dimethylpent-3-enoyl)oxy)pregnan-3,20-dione  0   *Pregnanediones. Chem Biodivers 2005 Jul;2(7):866-71
2beta,3alpha-dihydroxypregna-4,7,16-trien-12,20-dione  0   *Pregnanediones. Chem Pharm Bull (Tokyo). 2005 Mar;53(3):309-12
1alpha,2beta,3alpha-trihydroxypregna-4,7,16-trien-12,20-dione  0   *Pregnanediones. Chem Pharm Bull (Tokyo). 2005 Mar;53(3):309-12
17-acetoxy-4-bromopregn-4-ene-3,20-dione  0   *Pregnanediones. Anal Sci 2002 Aug;18(8):963-4
17-(5-bromovaleroyloxy)-16-methylpregna-4,6-diene-3,20-dione  0   *Pregnanediones. Anal Sci 2001 Jul;17(7):911-2
NM 135  0   *Pregnanediones Glucocorticoids. Jpn J Pharmacol 1998 Dec;78(4):505-9
ORG 21465  0   *Pregnanediones. Br J Anaesth 1997 Oct;79(4):427-32
3-hydroxy-2-(2,2-dimethyl-4-morpholinyl)pregnane-11,20-dione  0   *Morpholines *Pregnanediones. J Med Chem 1997 May 23;40(11):1668-81
21-chloro-3-hydroxy-2-(4-morpholinyl)pregnan-20-one  0   *Pregnanediones. Neuropharmacology 1996;35(9-10):1209-22
hydroxydione  303-01-5 Pregnane-3,20-dione, 21-hydroxy-, (5beta)  *Pregnanediones. Arzneim Forsch 25(10):1603;1975; Biol Reprod 21(2):433;1979; Endocrinology 103(4):1450;1978
21-diazo-4-methyl-4-azapregnane-3,20-dione  96692-00-1   *Azasteroids *Pregnanediones. J Biol Chem 1985;260(8):4890
4-aza-4-methylpregnane-3,20-dione  73671-90-6 4-Azapregnane-3,20-dione, 4-methyl-, (5alpha)  *Azasteroids *Pregnanediones. Endocrinology 1984;114(1):63
hydroxydione-21-succinate  13073-36-4   *Pregnanediones. Compr Ther 1982;8(12):59
alphadolone  14107-37-0 21-acetoxy-3-alpha-hydroxy-5-alpha-pregnane-11,20-dione  *Pregnanediones.
Pharma Action Anesthetics 		J Chromatogr 1981;226(1):213
6 beta-hydroxy-5 beta-pregnane-3,20-dione  57967-98-3   *Pregnanediones. Steroids 31(4):495;1978
16 beta-bromo-3 beta,17 alpha-dihydroxy-5 alpha-pregnane-11,20-dione  1780-98-9   *Pregnanediones Steroid 17-alpha-Hydroxylase/antagonists & inhibitors. J Endocrinol 71(3):289;1976
pregnane-3,17-diol-11,20-dione  56193-64-7 (3 alpha,5 beta)-3,17-dihydroxypregnane-11,20-dione  *Pregnanediones. Biochem Biophys Res Commun 53(4):1246;1973
alphaxalone  23930-19-0 3 alpha-hydroxy-5 alpha-pregnane-11,20-dione  *Pregnanediones.
Pharma Action Anesthetics 		Arzneimittelforsch 25(10):1603;1975; Biochem Pharmacol 1980;29(2):248; Br J Anaesth 47(8):902;1975; Br J Pharmacol 58:347;1976; Br J Pharmacol 58:359;1976; Br J Pharmacol 59(3):508;1977; Jap J Anesthesiol 23(6):527;1974; Nature 256(5514):179;1975; Vet Rec 102(13):283;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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